{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:41:40Z","timestamp":1789386100702,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study assesses the impact of a processed microvascular tissue (PMVT) allograft on wound closure and healing in a prospective, single\u2010blinded, multi\u2010centre, randomised controlled clinical trial of 100 subjects with Wagner Grade 1 and 2 chronic neuropathic diabetic foot ulcerations. In addition to standard wound care, including standardised offloading, the treatment arm received PMVT while the control arm received a collagen alginate dressing. The primary endpoint was complete wound closure at 12\u2009weeks. Secondary endpoints assessed on all subjects were percent wound area reduction, time to healing, and local neuropathy. Novel exploratory sub\u2010studies were conducted for wound area perfusion and changes in regional neuropathy. Weekly application of PMVT resulted in increased complete wound closure at 12\u2009weeks (74% vs 38%;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.0003), greater percent wound area reduction from weeks four through 12 (76% vs 24%;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.009), decreased time to healing (54\u2009days vs 64\u2009days;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.009), and improved local neuropathy (118% vs 11%;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.028) compared with the control arm. Enhanced perfusion and improved regional neuropathy were demonstrated in the sub\u2010studies. In conclusion, this study demonstrated increased complete healing with PMVT and supports its use in treating non\u2010healing DFUs. The observed benefit of PMVT on the exploratory regional neuropathy and perfusion endpoints warrants further study.\n                  <\/jats:p>","DOI":"10.1111\/iwj.13679","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T10:42:46Z","timestamp":1630492966000},"page":"811-825","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Improved healing of chronic diabetic foot wounds in a prospective randomised controlled multi\u2010centre clinical trial with a microvascular tissue allograft"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5167-4679","authenticated-orcid":false,"given":"Lisa J.","family":"Gould","sequence":"first","affiliation":[{"name":"South Shore Hospital  Weymouth Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis P.","family":"Orgill","sequence":"additional","affiliation":[{"name":"Professional Education and Research Institute  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"USC Keck School of Medicine  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Galiano","sequence":"additional","affiliation":[{"name":"Northwestern Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Glat","sequence":"additional","affiliation":[{"name":"Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5682-7056","authenticated-orcid":false,"given":"Charles M.","family":"Zelen","sequence":"additional","affiliation":[{"name":"Professional Education and Research Institute  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence A.","family":"DiDomenico","sequence":"additional","affiliation":[{"name":"Ankle &amp; Foot Care Centers  Youngstown Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa J.","family":"Carter","sequence":"additional","affiliation":[{"name":"Strategic Solutions, Inc.  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