{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:34:21Z","timestamp":1788449661712,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aims at evaluating the efficacy and safety of ozone therapy for chronic wounds. The Cochrane Library, PubMed, Ovid Embase, Web of Science, and Chinese Biomedical Literature Database were searched. Randomised controlled trials (RCTs) about participants with chronic wounds were included. Risk of bias assessment was performed by the Cochrane risk\u2010of\u2010bias tool. A randomised\u2010effects model was applied to pool results according to the types of wounds or ulcers. Among 12 included studies, ozone was implemented by topical application (ozone gas bath, ozonated oil, ozone water flushing) and systematic applications including autologous blood immunomodulation and rectal insufflation. The results indicated compared with standard control therapy for diabetic foot ulcers, ozone therapy regardless of monotherapy or combined control treatment markedly accelerated the improvement of the wound area(standardised mean difference(SMD)\u00a0=\u00a066.54%, 95% confidence interval (CI)\u00a0=\u00a0[46.18,86.90],\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.00001) and reduced the amputation rate (risk ration (RR)\u00a0=\u00a00.36, 95% CI\u00a0=\u00a0[0.24,0.54],\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.00001). But there is no improvement in the proportion of participants with completely healed wounds and length of hospital stay. No adverse events associated with ozone treatment have been reported. And the efficacy of ozone therapy for other wound types is still uncertain because of no sufficient studies. More high\u2010quality randomised controlled trials are needed to confirm the efficacy and safety of ozone therapy for chronic wounds or ulcers.\n                  <\/jats:p>","DOI":"10.1111\/iwj.13687","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T13:34:56Z","timestamp":1633700096000},"page":"853-870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["A systematic review of ozone therapy for treating chronically refractory wounds and ulcers"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3927-1823","authenticated-orcid":false,"given":"Qing","family":"Wen","sequence":"first","affiliation":[{"name":"Medical Department of Endocrinology Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongying","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical Department of Endocrinology Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Department of Endocrinology Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical Department of Endocrinology Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Fang","sequence":"additional","affiliation":[{"name":"Medical Department of Endocrinology Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianliang","family":"Qiu","sequence":"additional","affiliation":[{"name":"Medical Department of Endocrinology Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1224-1162","authenticated-orcid":false,"given":"Qiu","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical Department of Endocrinology Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.016782"},{"issue":"6","key":"e_1_2_11_3_1","first-page":"283","article-title":"Wound fluids and the pathogenesis of chronic wounds","volume":"23","author":"Wysocki AB","year":"1996","journal-title":"J Wound 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therapy for the treatment of chronic wounds: a systematic review","volume":"2018","author":"Fitzpatrick E","year":"2018","journal-title":"Int Wound J"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000020457"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.08.005"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S67826"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2018.11.060"},{"key":"e_1_2_11_28_1","first-page":"4","article-title":"Ozone application for preventing fungal infection in diabetic foot ulcers","author":"Ali EM","year":"2013","journal-title":"Diabetol 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Ozone bath in the treatment of diabetic foot ulcer infection","volume":"24","author":"Qin Xinyuan WL","year":"2020","journal-title":"Chin J Tissue Eng Res"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13410-019-00769-4"},{"issue":"3","key":"e_1_2_11_33_1","first-page":"210","article-title":"Non\u2010invasive oxygen\u2010ozone therapy in treating digital ulcers of patients with systemic sclerosis","volume":"43","author":"Hassanien M","year":"2018","journal-title":"Acta Reumatol Port"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000470155.29821.ed"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccw.2014.01.001"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2020.05.012"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0289-2"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e1119"},{"key":"e_1_2_11_39_1","first-page":"1","article-title":"Add\u2010on effect of Qiming granule, a Chinese patent medicine, in treating diabetic macular edema: a systematic review and meta\u2010analysis","volume":"2020","author":"Hu Z","year":"2020","journal-title":"Phytother Res"},{"key":"e_1_2_11_40_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions version 6.2","author":"Chandler J","year":"2021"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.13687","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iwj.13687","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.13687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T02:10:23Z","timestamp":1770948623000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.13687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,6]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/iwj.13687"],"URL":"https:\/\/doi.org\/10.1111\/iwj.13687","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,6]]},"assertion":[{"value":"2021-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}