{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:02:51Z","timestamp":1792270971627,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11902089"],"award-info":[{"award-number":["11902089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11672027"],"award-info":[{"award-number":["11672027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11827803"],"award-info":[{"award-number":["11827803"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20390"],"award-info":[{"award-number":["U20A20390"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Intermittent pneumatic compression (IPC) is commonly used to improve peripheral circulation of the lower extremity. However, its therapeutic dosage for people with type 2 diabetes mellitus (DM) at risk for ulcers is not well established. This study explored the effect of IPC with different inflation pressures on the distal microvascular responses of the foot in people with type 2 DM. Twenty\u2010four subjects with and without DM were recruited. Three IPC protocols with inflation pressures of 60, 90, and 120\u2009mmHg were applied to the foot. The foot skin blood flow (SBF) responses were measured by laser Doppler flowmetry during and after IPC interventions. Results show that all three IPC interventions significantly increased foot SBF of IPC stage in healthy subjects, but only 90 and 120\u2009mmHg IPC significantly improved SBF in diabetic subjects. IPC with 90 and 120\u2009mmHg showed a greater effect than 60\u2009mmHg in both groups, but 120\u2009mmHg IPC was more effective for diabetic subjects. This study demonstrates that 90 and 120\u2009mmHg are effective dosages of IPC for improving blood flow in healthy people, and 120\u2009mmHg IPC may be more suitable for people with type 2 DM.<\/jats:p>","DOI":"10.1111\/iwj.13693","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T22:05:45Z","timestamp":1631743545000},"page":"968-977","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of intermittent pneumatic compression with different inflation pressures on the distal microvascular responses of the foot in people with type 2 diabetes mellitus"],"prefix":"10.1111","volume":"19","author":[{"given":"Weiyan","family":"Ren","sequence":"first","affiliation":[{"name":"Key Laboratory of Rehabilitation Technical Aids for Old\u2010Age Disability, Key Laboratory of Human Motion Analysis and Rehabilitation Technology of the Ministry of Civil Affairs National Research Center for Rehabilitation Technical Aids  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Duan","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering Beihang University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7149-4034","authenticated-orcid":false,"given":"Yih\u2010Kuen","family":"Jan","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering Beihang University  Beijing China"},{"name":"Rehabilitation Engineering Laboratory, Department of Kinesiology and Community Health University of Illinois at Urbana\u2010Champaign  Champaign Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianchao","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering Beihang University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering Beihang University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1467-006X","authenticated-orcid":false,"given":"Fang","family":"Pu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering Beihang University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering Beihang University  Beijing China"},{"name":"School of Engineering Medicine Beihang University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v5.i4.546"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67696-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-1614"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1004"},{"issue":"7","key":"e_1_2_9_6_1","first-page":"1","article-title":"Impact of diabetes and peripheral arterial occlusive disease on the functional microcirculation at the plantar foot","volume":"1","author":"Kabbani M","year":"2013","journal-title":"Plast Reconstr Surg"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(96)00134-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.895229"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1191\/1358863x02vm423oa"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X14552096"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.11.044"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2001.1466"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-001-0297-8"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.11.043"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.08.094"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.1999.1047"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/phy2.157"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2013.05.004"},{"issue":"2019","key":"e_1_2_9_19_1","first-page":"1","article-title":"Effects of local vibration with different intermittent durations on skin blood flow responses in diabetic people","volume":"7","author":"Ren W","year":"2019","journal-title":"Front Bioeng Biotechnol"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.06.004"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2014.06.007"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2005.07.022"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.11.006"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00006.2010"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1949.1.9.649"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.10.1810"},{"issue":"1","key":"e_1_2_9_27_1","first-page":"87","article-title":"Intermittent pneumatic compression therapy in lower leg venous \u2013 lymphatic disorders","volume":"39","author":"Ponikowska IGK","year":"1997","journal-title":"Balneol Pol"},{"issue":"11","key":"e_1_2_9_28_1","first-page":"293","article-title":"Effect of high\u2010pressure, intermittent pneumatic compression for the treatment of peripheral arterial disease and critical limb ischemia in patients without a surgical option","volume":"27","author":"Alvarez OM","year":"2015","journal-title":"Wounds"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.10.1173"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2011.03.015"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/03091900601015147"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physrep.2009.12.003"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2009.05.004"},{"issue":"2015","key":"e_1_2_9_34_1","first-page":"1","article-title":"Increment of body mass index is positively correlated with worsening of endothelium\u2010dependent and independent changes in forearm blood flow","volume":"6","author":"Kraemer\u2010Aguiar LG","year":"2015","journal-title":"Front Physiol"},{"key":"e_1_2_9_35_1","first-page":"18","volume-title":"Vascular Surgery","author":"Sumner DS","year":"1995"},{"key":"e_1_2_9_36_1","first-page":"1","volume-title":"Lower Limb Ischaemia","author":"Sumner DS","year":"1997"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0092-1"},{"issue":"2","key":"e_1_2_9_38_1","first-page":"55","article-title":"In defense of microvascular constriction in diabetes","volume":"25","author":"Wiernsperger NF","year":"2001","journal-title":"Clin Hemorheol Microcirc"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.42.3.375"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.2.344"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.17.4.284"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000040250.31755.F9"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2002.121126"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.04.009"},{"issue":"4","key":"e_1_2_9_45_1","first-page":"583","article-title":"The effect of a mechanical venous pump on the circulation of the feet in the presence of arterial obstruction","volume":"146","author":"Gaskell P","year":"1978","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2000.107570"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.13693","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iwj.13693","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.13693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T20:39:13Z","timestamp":1744576753000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.13693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,15]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/iwj.13693"],"URL":"https:\/\/doi.org\/10.1111\/iwj.13693","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,15]]},"assertion":[{"value":"2021-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}