{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T04:10:45Z","timestamp":1749787845239,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30872685","81272110"],"award-info":[{"award-number":["30872685","81272110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Scar formation and chronic ulcers can develop following a skin injury. They are the result of the over\u2010 or underproduction of collagen. It is very important to evaluate the quality and quantity of the collagen that is produced during wound healing, especially with respect to its structure, as these factors are very important to a complicated outcome. However, there is no standard way to quantitatively analyse dermal collagen. As prior work characterised some potentially fractal properties of collagen, it was hypothesised that collagen structure could be evaluated with fractal dimension analysis. Small\u2010angle X\u2010ray scattering technology (SAXS) was used to evaluate the dermis of rats exposed to graft harvest, burn, and diabetic pathologic states. It was found that almost all collagen structures could be quantitatively measured with fractal dimension analysis. Further, there were significant differences in the three\u2010dimensional (3\u2010D) structure of normal collagen versus that measured in pathologic tissues. There was a significant difference in the 3\u2010D structure of collagen at different stages of healing. The findings of this work suggest that fractal analysis is a good tool for wound healing analysis, and that quantitative collagen analysis is very useful for assessing the structure of dermal collagen.<\/jats:p>","DOI":"10.1111\/iwj.13698","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T05:34:10Z","timestamp":1633757650000},"page":"1016-1022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fractal analysis of rat dermal tissue in the different injury states"],"prefix":"10.1111","volume":"19","author":[{"given":"Haisong","family":"Xu","sequence":"first","affiliation":[{"name":"Shanghai Burns Institute, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University  Shanghai China"},{"name":"The department of plastic surgery, Shanghai 9<sup>th<\/sup> Hospital Shanghai Jiaotong University, School of Medicine  Shanghai 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