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Phytochemicals are easily accessible, low in toxicity, and have various biological and pharmacological properties. Oxymatrine is a phytochemical that regulates autophagy networks. Autophagy is closely related to the maintenance, activity, differentiation, and life\u2010death of skin fibroblasts during wound repair, which results in pathological scars. We hypothesised that oxymatrine may promote hypertrophic scar repair by inhibiting fibroblast autophagy. In vitro studies showed that inhibition of autophagy by oxymatrine decreased viability and collagen metabolism, and increased apoptosis of human scar fibroblasts (HSFs). In vivo studies showed that inhibition of autophagy by oxymatrine promoted scar repair, resulting in a significantly improved final outcome of the hypertrophic scars, a smaller scar area, decreased epidermal and dermal thickness, and a significant downregulation of CK10, P63, collagen I, \u03b1\u2010SMA, and TGF\u2010\u03b21. In summary, oxymatrine promoted hypertrophic scar repair by decreasing HSF viability and collagen, and inducing apoptosis via autophagy inhibition. This study provides a new perspective on the mechanism of hypertrophic burn scar formation, as well as key scientific data for the application of the phytochemical oxymatrine as a new method for the prevention and treatment of hypertrophic scars.<\/jats:p>","DOI":"10.1111\/iwj.13717","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:59:08Z","timestamp":1636419548000},"page":"1221-1231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Oxymatrine promotes hypertrophic scar repair through reduced human scar fibroblast viability, collagen and induced apoptosis via autophagy inhibition"],"prefix":"10.1111","volume":"19","author":[{"given":"Xingwang","family":"Deng","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Ningxia Medical University  Yinchuan China"},{"name":"Department of Burns and Plastic Surgery The First People's Hospital of Shizuishan  Shizuishan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Tissue Organ Bank &amp; Tissue Engineering Centre, General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Tissue Organ Bank &amp; Tissue Engineering Centre, General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tissue Organ Bank &amp; Tissue Engineering Centre, General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Tissue Organ Bank &amp; Tissue Engineering Centre, General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Ningxia Medical University  Yinchuan China"},{"name":"Department of Burns and Plastic Surgery Xinyang Central Hospital  Xinyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Qiang","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Ningxia Medical University  Yinchuan China"},{"name":"Department of Burns and Plastic Surgery People's Hospital of Ningxia Hui Autonomous Region  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Xie","sequence":"additional","affiliation":[{"name":"Beijing Engineering Lab for Cell Therapy  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Tissue Organ Bank &amp; Tissue Engineering Centre, General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Pan","sequence":"additional","affiliation":[{"name":"Tissue Organ Bank &amp; Tissue Engineering Centre, General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinsheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery General Hospital of Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xie","sequence":"additional","affiliation":[{"name":"Tissue Organ Bank &amp; Tissue Engineering Centre, General Hospital of Ningxia Medical University  Yinchuan China"},{"name":"School of Biomedical Sciences, Faculty of Health Queensland University of Technology  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31406-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0145-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2009.00153"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012252"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-192602000-00002"},{"issue":"10","key":"e_1_2_10_7_1","first-page":"672","article-title":"Reconsideration of burn scar treatment. 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