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This study aims to characterise the major clinical outcomes of forementioned three groups of lower extremity wound patients in Singapore. Patients hospitalised for lower extremity NIU between January 2014 and October 2017 in a tertiary hospital in Singapore were analysed. Patients' major limb amputation and mortality were assessed using Cox regression models. Cumulative survival and amputation\u2010free survival among the three classified groups were calculated using Kaplan\u2010Meier analysis. Compared with patients with only DM, those in the PAD group and the DM\u2010PAD group had higher risk of major limb amputation (adjusted hazard ratio: 2.47, 95% CI: 1.65\u20103.70; adjusted hazard ratio: 2.01, 95% CI: 1.53\u20102.65 respectively) and mortality (adjusted hazard ratio: 2.36, 95% CI: 1.57\u20103.55; adjusted hazard ratio: 2.46, 95% CI: 1.86\u20103.26 respectively). The 3\u2010year survival and amputation\u2010free survival were lowest in the DM\u2010PAD group (52.1% and 41.5% respectively), followed by the PAD group (53.3% and 44.6% respectively) and the DM group (74.2% and 68.5% respectively). Lower extremity NIU patients with PAD or DM\u2010PAD were found to have poorer clinical prognosis than those with DM only.<\/jats:p>","DOI":"10.1111\/iwj.13724","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T09:39:45Z","timestamp":1639647585000},"page":"1298-1308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Major limb amputation and mortality in patients with neuro\u2010ischaemic lower extremity wounds managed in a tertiary hospital: Focus on the differences among patients with diabetes, peripheral arterial disease and both"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0205-6801","authenticated-orcid":false,"given":"Lingyan","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Surgery Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5559-3267","authenticated-orcid":false,"given":"Nicholas","family":"Graves","sequence":"additional","affiliation":[{"name":"Health Services &amp; Systems Research Duke\u2010NUS Medical School  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo Chen","family":"Du","sequence":"additional","affiliation":[{"name":"Biostatistics Unit Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Yi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koy Min","family":"Chue","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Surgery National University Health System  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur Nabila Farhana","family":"Binte Taufiq Chong Ah Hoo","sequence":"additional","affiliation":[{"name":"Department of Surgery Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuraini","family":"Nazeha","sequence":"additional","affiliation":[{"name":"Health Services &amp; Systems Research Duke\u2010NUS Medical School  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Zhen","family":"Ng","sequence":"additional","affiliation":[{"name":"Wound Care Innovation for the Tropics Programme Skin Research Institute of Singapore, A*STAR  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Harding","sequence":"additional","affiliation":[{"name":"Wound Care Innovation for the Tropics Programme Skin Research Institute of Singapore, A*STAR  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4560-2374","authenticated-orcid":false,"given":"Pei","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Surgery Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"},{"name":"Department of Cardiac, Thoracic and Vascular Surgery National University Health System  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12683"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13953"},{"issue":"3","key":"e_1_2_9_4_1","first-page":"130","article-title":"An economic evaluation of chronic wound management in a tertiary hospital","volume":"24","author":"Tan B","year":"2016","journal-title":"Wound Pract Res"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13333"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.07.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","unstructured":"StarA.Peripheral arterial disease: Differentiating lower extremity wounds: Arterial venous neurotrophic. 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