{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:10:23Z","timestamp":1790835023877,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetes\u2010related lower extremity amputations are an enormous burden on global health care and social resources because of the rapid worldwide growth of the diabetic population. This research aimed to determine risk factors that predict major amputation and analyse the time interval from first hospitalisation to amputation by using standard management protocols and Kaplan\u2013Meier survival curves. Data from 246 patients with diabetes mellitus and diabetic foot ulcers from the Division of Plastic and Reconstructive Surgery of the Department of Surgery at XXX Hospital between January 2016 and May 2020 were analysed. Univariate and multivariate analyses of 44 potential risk factors, including invasive ulcer depth and C\u2010reactive protein levels, showed statistically significant differences for those at increased risk for major amputation. The median time from hospitalisation to lower extremity amputation was approximately 35\u2009days. Most patients with abnormal C\u2010reactive protein levels and approximately 70% of patients with ulcers invading the bone were at risk for lower extremity amputations within 35\u2009days. Therefore, invasive ulcer depth and C\u2010reactive protein levels are significant risk factors. Other potential risk factors for major amputation and the time intervals from first hospitalisation to amputation should be analysed to establish further prediction strategies.<\/jats:p>","DOI":"10.1111\/iwj.13727","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:39:10Z","timestamp":1639010350000},"page":"1329-1338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Risk factors that predict major amputations and amputation time intervals for hospitalised diabetic patients with foot complications"],"prefix":"10.1111","volume":"19","author":[{"given":"Yu\u2010Yu","family":"Chou","sequence":"first","affiliation":[{"name":"Division of Plastic Surgery, Department of Surgery Tri\u2010Service General Hospital, National Defense Medical Center  Taipei 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