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The databases searched were Medline PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Library, Embase, Web of Science, and Scopus. Data synthesis and analysis were conducted using a structured narrative synthesis. The quality of the included clinical studies was appraised using the Evidence\u2010Based Literature (EBL) Critical Appraisal Tool. A total of six clinical studies were assessed as eligible for inclusion, A total of six dressings\/topical agents were assessed and the types of wounds included non\u2010healing chronic wounds. Of the studies, five explored pH and one explored temperature. The EBL validity of the clinical studies was low (mean quality score was 51.3%). The five clinical studies that explored pH investigated different dressings and topical agents reporting an associated reduction in pH and improved wound outcomes. One clinical study investigated the impact of topical sodium nitrite on temperature and found that sodium nitrite increased peri\u2010wound skin temperature and improved wound outcomes with a reduction in leg ulcer size. Given the low certainty of the evidence, we cannot confidently recommend the use of any particular topical agent or dressing to manipulate pH, or temperature to improve wound outcomes. Thus, there is a need for further research to develop a greater understanding of this topic. Irish Research Council, Enterprise Partnership Scheme.<\/jats:p>","DOI":"10.1111\/iwj.13733","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T03:33:00Z","timestamp":1640057580000},"page":"1397-1408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["The impact of topical agents and dressing on <scp>pH<\/scp> and temperature on wound healing: A systematic, narrative review"],"prefix":"10.1111","volume":"19","author":[{"given":"Rosemarie","family":"Derwin","sequence":"first","affiliation":[{"name":"School of Nursing and Midwifery, The Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan","family":"Patton","sequence":"additional","affiliation":[{"name":"Wounds and Trauma Research Centre, School of Nursing and Midwifery, The Royal College of Surgeons in Ireland 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