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This study aimed to review the risks and benefits of NPWT in surgical wounds with the underlying malignant disease compared with conventional wound care (CWC). The first outcome was wound complications, divided into surgical site infection (SSI), seroma, hematoma, and wound dehiscence. The secondary outcome was hospital readmission. We performed a separate meta\u2010analysis of observational studies and randomised controlled trials (RCTs) with CI 95%. Thirteen observational studies with 1923 patients and seven RCTs with 1091 patients were included. NPWT group showed significant decrease in the risk of SSI (RR\u00a0=\u00a00.45) and seroma (RR\u00a0=\u00a00.61) in observational studies with <jats:italic>P<\/jats:italic> value &lt;0.05, as well as RCTs but were not significant (RR\u00a0=\u00a00.88 and RR\u00a0=\u00a00.68). Wound dehiscence (RR\u00a0=\u00a00.74 and RR\u00a0=\u00a01.15) and hospital readmission (RR\u00a0=\u00a00.90 and RR\u00a0=\u00a00.62) showed lower risks in NPWT group but were not significant. Hematoma (RR\u00a0=\u00a01.08 and RR\u00a0=\u00a00.87) showed no significant difference. NPWT is not contraindicated in cancer surgical wounds and can be considered a beneficial palliative treatment to promote wound healing.<\/jats:p>","DOI":"10.1111\/iwj.13756","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T03:44:58Z","timestamp":1643859898000},"page":"1578-1593","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Negative pressure wound therapy versus conventional wound care in cancer surgical wounds: A meta\u2010analysis of observational studies and randomised controlled trials"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6668-6496","authenticated-orcid":false,"given":"Indri Lakhsmi","family":"Putri","sequence":"first","affiliation":[{"name":"Department of Plastic Reconstructive and Aesthetic Surgery Faculty of Medicine, Airlangga University  Surabaya Indonesia"},{"name":"Plastic Reconstructive and Aesthetic Surgery Unit Airlangga University Hospital  Surabaya Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavonia Berlina","family":"Adzalika","sequence":"additional","affiliation":[{"name":"Plastic Reconstructive and Aesthetic Surgery Unit Airlangga University Hospital  Surabaya Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachmaniar","family":"Pramanasari","sequence":"additional","affiliation":[{"name":"Plastic Reconstructive and Aesthetic Surgery Unit Airlangga University Hospital  Surabaya Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Citrawati Dyah Kencono","family":"Wungu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Medical Biochemistry, Faculty of Medicine Airlangga University  Surabaya Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_9_3_1","unstructured":"World Health Organization (WHO).Global Health Estimates 2020: Deaths by Cause Age Sex by Country and by Region 2000\u20132019. 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