{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:11:26Z","timestamp":1792721486163,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T00:00:00Z","timestamp":1643155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T00:00:00Z","timestamp":1643155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diabetic foot ulcers (DFUs) pose a significant risk for infection and limb loss. Advanced wound therapies including human skin allografts have shown promise in resolving these challenging wounds. The primary objective of this randomised, prospective study was to compare the response of 100 subjects with non\u2010healing DFUs of which 50 were treated with a cryopreserved bioactive split thickness skin allograft (BSA) (TheraSkin; Misonix,Inc., Farmingdale, NY) compared with 50 subjects treated with standard of care (SOC, collagen alginate dressing) at 12\u2009weeks. Both groups received standardised care that included glucose monitoring, weekly debridement's as appropriate, and an offloading device. The primary endpoint was proportion of full\u2010thickness wounds healed at 12\u2009weeks, with secondary endpoints including differences in percent area reduction (PAR) at 12\u2009weeks, changes in Semmes\u2010Weinstein monofilament score, VAS pain, and w\u2010QoL. The result illustrated in the intent\u2010to\u2010treat analysis at 12\u2009weeks showed that 76% (38\/50) of the BSA\u2010treated DFUs healed compared with 36% (18\/50) treated with SOC alone (adjusted\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u2009.00056). Mean PAR at 12\u2009weeks was 77.8% in the BSA group compared with 49.6% in the SOC group (adjusted\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u2009.0019). In conclusion, adding BSA to SOC appeared to significantly improve wound healing with a lower incidence of adverse events related to treatment compared with SOC alone.\n                  <\/jats:p>","DOI":"10.1111\/iwj.13759","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T04:14:27Z","timestamp":1643170467000},"page":"932-944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Multi\u2010centre prospective randomised controlled clinical trial to evaluate a bioactive split thickness skin allograft vs standard of care in the treatment of diabetic foot ulcers"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1887-9175","authenticated-orcid":false,"given":"David G.","family":"Armstrong","sequence":"first","affiliation":[{"name":"Department of Surgery, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9552-6483","authenticated-orcid":false,"given":"Robert D.","family":"Galiano","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8279-7310","authenticated-orcid":false,"given":"Dennis P.","family":"Orgill","sequence":"additional","affiliation":[{"name":"Professional Education and Research Institute  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5009-8603","authenticated-orcid":false,"given":"Paul M.","family":"Glat","sequence":"additional","affiliation":[{"name":"Department of Surgery Drexel University School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2265-6639","authenticated-orcid":false,"given":"Marissa J.","family":"Carter","sequence":"additional","affiliation":[{"name":"Strategic Solutions, Inc  Bozeman Montana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence A.","family":"Di Domenico","sequence":"additional","affiliation":[{"name":"Lower Extremity Institute for Research and Therapy  Youngstown Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2642-6184","authenticated-orcid":false,"given":"Alexander M.","family":"Reyzelman","sequence":"additional","affiliation":[{"name":"Center for Clinical Research  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5682-7056","authenticated-orcid":false,"given":"Charles M.","family":"Zelen","sequence":"additional","affiliation":[{"name":"Professional Education and Research Institute  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra16154392"},{"issue":"1","key":"e_1_2_7_3_1","first-page":"S63","article-title":"Preventive foot care in diabetes","volume":"27","author":"Mayfield JA","year":"2004","journal-title":"Diabetes 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