{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:19:31Z","timestamp":1787167171715,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Multiple clinical trials and real\u2010world studies have demonstrated accelerated healing in diabetic foot ulcers (DFU) treated with advanced modalities, such as topical oxygen therapy (TOT). In addition to healing, the durability of wound closure is a crucial long\u2010term endpoint for DFU clinical trials: an advanced treatment that does not confer a reasonable ulcer\u2010free period will have limited clinical benefit and modest economic value. Preclinical studies suggest that DFUs receiving topical oxygen therapy will experience improved quality of healing: increased collagen deposition and angiogenesis. It is postulated that these changes will translate into a more long\u2010lasting closure for ulcers treated with TOT and SOC compared to ulcers treated with SOC alone. At the conclusion of a recently completed randomised controlled DFU clinical trial evaluating the efficacy of TOT and SOC compared to SOC alone, patients with healed ulcers were asked to enrol in a long\u2010term follow\u2010up study. Healed patients completed four questionnaires through text messages or phone calls within 1\u2010year post completion of the trial. Twenty\u2010nine patients consented to participate in the long\u2010term follow\u2010up trial (17 TOT\/SOC and 12 SOC). Only seven subjects were lost to follow up (5 TOT and 2 SOC). This is a surprisingly low number when factoring in the disruption caused by the COVID\u201019 pandemic that continued throughout the entire follow\u2010up period. In the remaining patients, 85% of the TOT patients and 60% of the SOC remained healed at 1\u00a0year. There was one major amputation, which occurred in an SOC\u2010treated patient. The numbers in the long\u2010term follow\u2010up were too small to reach statistical significance; however, there is a strong trend toward more durable closure in ulcers treated with TOT.<\/jats:p>","DOI":"10.1111\/iwj.13789","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T03:39:33Z","timestamp":1650339573000},"page":"1838-1842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A multicenter clinical trial evaluating the durability of diabetic foot ulcer healing in ulcers treated with topical oxygen and standard of care versus standard of care alone 1\u2009year post healing"],"prefix":"10.1111","volume":"19","author":[{"given":"Omar","family":"Al\u2010Jalodi","sequence":"first","affiliation":[{"name":"SerenaGroup\u00ae Research Foundation  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Kupcella","sequence":"additional","affiliation":[{"name":"SerenaGroup\u00ae Research Foundation  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"Breisinger","sequence":"additional","affiliation":[{"name":"SerenaGroup\u00ae Research Foundation  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1032-3578","authenticated-orcid":false,"given":"Thomas E.","family":"Serena","sequence":"additional","affiliation":[{"name":"SerenaGroup\u00ae Research Foundation  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2707"},{"issue":"1","key":"e_1_2_7_3_1","first-page":"10","article-title":"Wound care outcomes and associated cost among patients treated in US outpatient wound centers: data from the US wound registry","volume":"24","author":"Fife CE","year":"2012","journal-title":"Wounds"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.7547\/1030161"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101681.2008.04934.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199111000-00011"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2018.27.Sup9.S30"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19\u20100476"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2021.30.Sup5.S7"},{"key":"e_1_2_7_11_1","volume-title":"IDF Diabetes Atlas","author":"IDF","year":"2017"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09\u20100651"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/CWCMR.S260136"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.13789","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iwj.13789","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.13789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T20:55:12Z","timestamp":1744577712000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.13789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,19]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/iwj.13789"],"URL":"https:\/\/doi.org\/10.1111\/iwj.13789","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,19]]},"assertion":[{"value":"2021-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}