{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:43:49Z","timestamp":1791819829458,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Identification of novel markers would contribute to the individualised risk assessment and development of a risk prediction model. This study aimed to investigate the role of the C\u2010reactive protein to albumin ratio (CAR) in predicting surgical site infection (SSI) following instrumented posterior lumbar interbody fusion (PLIF) of lumbar degenerative diseases. This study enrolled patients who underwent PLIF and instrumentation for treatment of lumbar degenerative diseases between 2015 and 2020. Electronic medical records were inquired for data collection, with follow\u2010up register for identifying SSI cases. The optimal cut\u2010off for CAR was determined by constructing the receiver operator characteristic (ROC) curve. Patients with high\u2010 or low\u2010CAR value were compared using the univariate analyses, and the association between CAR and the risk of SSI was investigated using multivariate logistics regression analysis. A total of 905 patients were enrolled, twenty\u2010nine (3.2%) had developed an SSI with 72.4% occurring during index hospitalisation, and 11 (1.2%) had deep and 18 (2.0%) superficial SSIs. An SSI was associated with additional 10.7\u2009days of index total hospital stay (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). The CAR was 0\u20135.43 (median, 0.05), and the optimal cut\u2010off was 0.09 and area under the curve was 0.720 (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). 336 (37.1%) patients had a CAR \u22650.09 and 22 (6.5%) developed an SSI, with a crude risk of 5.6 relative to those with a low CAR. The multivariate analyses showed CAR \u22650.09 was associated with 8.06\u2010fold increased risk of SSI, together with diabetes (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.018), while hypertension was identified as a protective factor (OR, 0.34; 95%CI, 0.11\u20131.00, <jats:italic>P<\/jats:italic>\u00a0=\u2009.049). High CAR is found to significantly predict the incident SSI following instrumented PLIF of lumbar degenerative diseases, and can be considered as a useful index in practice only after it is verified by future high\u2010level evidences.<\/jats:p>","DOI":"10.1111\/iwj.13843","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T09:39:06Z","timestamp":1652780346000},"page":"92-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["C\u2010reactive protein to albumin ratio (<scp>CAR<\/scp>) in predicting surgical site infection (<scp>SSI<\/scp>) following instrumented posterior lumbar interbody fusion (<scp>PLIF<\/scp>)"],"prefix":"10.1111","volume":"20","author":[{"given":"Shaozheng","family":"Qu","sequence":"first","affiliation":[{"name":"Department of orthopaedic surgery Yantai Yuhuangding Hospital  Yantai 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