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Patients with urinary infections are at risk of developing IAD, and to guide the development of novel prevention strategies, we aimed to develop an animal model of IAD by urine and bacteria. First, contralateral sites on the dorsal skin of Sprague\u2013Dawley rats were compromised by sodium lauryl sulphate (SLS), simulating frequent cleansing with soap\/water. Filter discs were then placed inside ring\u2010shaped chambers on foam dressings, inoculated with or without <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, covered with agarose gels immersed in cultured filtrated urine, and secured in place with an occlusive dressing for 3\u2009days. Untreated and SLS\u2010compromised sites served as controls. The IAD was developed at bacteria\u2010inoculated sites, characterised by severe IAD\u2010like redness that persisted for up to 3\u2009days post\u2010exposure and higher disruption of the skin barrier function compared with non\u2010inoculated sites. Pathological changes included epidermal thickening, partial skin loss, inflammatory cell infiltration, accumulation of red blood cells, and invasion of bacteria into the epidermis. This novel, clinically relevant IAD rat model can serve for future prevention developments.<\/jats:p>","DOI":"10.1111\/iwj.13864","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T16:38:05Z","timestamp":1659458285000},"page":"191-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Bacterial invasion into the epidermis of rats with sodium lauryl sulphate\u2010irritated skin increases damage and induces incontinence\u2010associated dermatitis"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3915-2322","authenticated-orcid":false,"given":"Sofoklis","family":"Koudounas","sequence":"first","affiliation":[{"name":"Department of Skincare Science, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5859-7290","authenticated-orcid":false,"given":"Takeo","family":"Minematsu","sequence":"additional","affiliation":[{"name":"Department of Skincare Science, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Global Nursing Research Center, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Mugita","sequence":"additional","affiliation":[{"name":"Department of Gerontological Nursing, Wound Care Management, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayano","family":"Nakai","sequence":"additional","affiliation":[{"name":"Global Nursing Research Center, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Tobe","sequence":"additional","affiliation":[{"name":"Global Nursing Research Center, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Gerontological Nursing, Wound Care Management, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Kunimitsu","sequence":"additional","affiliation":[{"name":"Department of Gerontological Nursing, Wound Care Management, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gojiro","family":"Nakagami","sequence":"additional","affiliation":[{"name":"Global Nursing Research Center, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Gerontological Nursing, Wound Care Management, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Sanada","sequence":"additional","affiliation":[{"name":"Global Nursing Research Center, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Gerontological Nursing, Wound Care Management, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","article-title":"Proceedings of the global IAD expert panel. 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