{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:49:31Z","timestamp":1791643771744,"version":"4.3.4"},"reference-count":109,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This meta\u2010review aimed to appraise and synthesise findings from existing systematic reviews that measured the impact of compression therapy on venous leg ulcers healing. We searched five databases to identify potential papers; three authors extracted data, and a fourth author adjudicated the findings. The AMSTAR\u20102 tool was used for quality appraisal and the certainty of the evidence was appraised using GRADEpro. Data analysis was undertaken using RevMan. We identified 12 systematic reviews published between 1997 and 2021. AMSTAR\u20102 assessment identified three as high quality, five as moderate quality, and four as low quality. Seven comparisons were reported, with a meta\u2010analysis undertaken for five of these comparisons: compression vs no compression (risk ratio [RR]: 1.55; 95% confidence interval [CI] 1.34\u20101.78;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u2009.00001; moderate\u2010certainty evidence); elastic compression vs inelastic compression (RR: 1.02; 95% CI: 0.96\u20101.08;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u2009.61 moderate\u2010certainty evidence); four layer vs &lt;four\u2010layer bandage systems (RR: 1.07; 95% CI: 0.82\u20101.40;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u2009.63; moderate\u2010certainty evidence); comparison between different four\u2010layer bandage systems (RR: 1.08; 95% CI: 0.93\u20101.25;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u2009.34; moderate\u2010certainty evidence); compression bandage vs compression stocking (RR 0.95; 95% CI 0.87\u20101.03;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u2009.18; moderate\u2010certainty evidence). The main conclusion from this review is that there is a statistically significant difference in healing rates when compression is used compared with no compression, with moderate\u2010certainty evidence. Otherwise, there is no statistically different difference in healing rates using elastic compression vs inelastic compression, four layer vs &lt;four\u2010layer bandage systems, different four\u2010layer bandage systems, or compression bandages vs compression stockings.\n                  <\/jats:p>","DOI":"10.1111\/iwj.13891","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:38:49Z","timestamp":1658191129000},"page":"430-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["A meta\u2010review of the impact of compression therapy on venous leg ulcer healing"],"prefix":"10.1111","volume":"20","author":[{"given":"Declan","family":"Patton","sequence":"first","affiliation":[{"name":"Skin Wounds and Trauma Research Centre The Royal College of Surgeons in Ireland (RCSI), University of Medicine and Health Sciences  Dublin Ireland"},{"name":"School of Nursing and Midwifery The Royal 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