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Quantitative real\u2010time PCR method was used to determine miR\u2010103 expression levels in the wound margin tissue of subjects, and to analyse the relationship between the expression of miR\u2010103 and DFU wound healing. In vitro experiments were also performed to understand the effect of miR\u2010103 on the high glucose\u2010induced injury of normal human dermal fibroblasts (NHDFs) cells. The results showed that the miR\u2010103 expression level in the DFU group was significantly higher than that in the SUC group [5.81 (2.25\u20139.36) vs 2.08 (1.15\u20135.72)] (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The expression level of miR\u2010103 in the wound margin tissue of DFU was negatively correlated with the healing rate of foot ulcers after four weeks (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.037). In vitro experiments revealed that miR\u2010103 could inhibit the proliferation and migration of NHDF cells and promote the apoptosis of NHDF cells by targeted regulation of regulator of calcineurin 1 (RCAN1) gene expression in a high glucose environment. Down\u2010regulation of miR\u2010103 could alleviate high glucose\u2010induced NHDF cell injury by promoting RCAN1 expression. Therefore, the increased expression of miR\u2010103 is involved in the functional damage of NHDF cells induced by high\u2010glucose conditions, which is related to poor wound healing of DFU. These research findings will provide potential targets for the diagnosis and treatment of chronic skin wounds in diabetes.<\/jats:p>","DOI":"10.1111\/iwj.13895","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T07:39:42Z","timestamp":1657870782000},"page":"467-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Changes in miroRNA\u2010103 expression in wound margin tissue are related to wound healing of diabetes foot ulcers"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3736-6973","authenticated-orcid":false,"given":"Xiaotong","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Endocrinology the First Affiliated Hospital of Anhui Medical University  Hefei People's Republic of 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