{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:10:09Z","timestamp":1780729809417,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The performance and safety of Exufiber\u00ae gelling fibre and Aquacel\u00ae Extra\u2122 Hydrofiber\u00ae wound dressings were compared for the management of chronic, exuding leg ulcers. The 6\u2010week study (\u2264\u200924\u2009weeks in a subgroup of subjects) was a randomised, open\u2010label, parallel\u2010group, multicentre, non\u2010inferiority design. Adults (n\u00a0=\u00a0248, 30\u201397\u2009years of age) were randomised to either Exufiber\u00ae or Aquacel\u00ae Extra\u2122 dressing. The dressings were applied at baseline and evaluations of wound condition and performance of the dressing were recorded at 1, 2, 3, 4, and 6\u2009weeks. The primary efficacy endpoint was the percentage reduction in wound area at 6\u2009weeks relative to baseline, in the per protocol (PP) population. A median relative reduction of 50% for Exufiber\u00ae (n\u00a0=\u00a0100) vs 42% for Aquacel\u00ae Extra\u2122 (n\u00a0=\u00a0107) was demonstrated in the PP population (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.093) and confirmed in the intention\u2010to\u2010treat population. As the mean and 95% confidence interval for the difference in relative wound area reduction between groups at 6\u2009weeks was \u221229.4% (\u221263.5; 3.2), and the lower limit did not exceed 12%, non\u2010inferiority of Exufiber\u00ae was concluded. Both dressings were well tolerated and no safety concerns were identified in both groups. Clinicians' satisfaction with the dressings was higher for Exufiber\u00ae than for Aquacel\u00ae Extra\u2122 in terms of ease of use and management of exudate, slough, and blood.<\/jats:p>","DOI":"10.1111\/iwj.13913","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T09:26:27Z","timestamp":1663320387000},"page":"22-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A randomised, open\u2010label, parallel\u2010group, multicentre, comparative study to compare the efficacy and safety of Exufiber\u00ae with Aquacel\u00ae Extra\u2122 dressings in exuding venous and mixed aetiology leg ulcers"],"prefix":"10.1111","volume":"19","author":[{"given":"Bo","family":"Joergensen","sequence":"first","affiliation":[{"name":"Bispebjerg Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7238-112X","authenticated-orcid":false,"given":"Sophie","family":"Blaise","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine Grenoble Alpes University Hospital  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Sofie","family":"Svensson","sequence":"additional","affiliation":[{"name":"M\u00f6lnlycke Health Care  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Wound Exudate: Effective Assessment and Management","author":"World Union of Wound Healing Societies","year":"2019"},{"key":"e_1_2_10_3_1","unstructured":"AlvarezO GranickM.A new multilayer wound dressing that transports toxic matrix metalloproteases from chronic wound fluid away from the wound (Abstract CS\u2010002). Presented at the Symposium on Advanced Wound Care (SAWC) Fall meeting; 12\u201014 November 2019; Las Vegas Nevada USA."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2015.24.Sup15.S8"},{"issue":"3","key":"e_1_2_10_5_1","first-page":"35","article-title":"Changing the way we look at viscous exudate","volume":"6","author":"Vowden P","year":"2015","journal-title":"Wounds Int"},{"issue":"1","key":"e_1_2_10_6_1","first-page":"45","article-title":"An evaluation of properties related to wear time of four dressings during a five\u2010day period","volume":"11","author":"Rippon M","year":"2015","journal-title":"Wounds UK"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2012.21.8.359"},{"issue":"1","key":"e_1_2_10_8_1","first-page":"43","article-title":"Exudate management using a gelling fibre dressing","volume":"18","author":"Chadwick P","year":"2015","journal-title":"Diabet Foot J"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2013.22.Sup1.S1"},{"issue":"8","key":"e_1_2_10_10_1","first-page":"229","article-title":"Evidence of intensive autolytic debridement with a self\u2010adaptive wound dressing","volume":"27","author":"Reyzelman AM","year":"2015","journal-title":"Wounds Compend Clin Res Pract"},{"issue":"38","key":"e_1_2_10_11_1","first-page":"s40","article-title":"Effective management of exudate with AQUACEL extra","volume":"17","author":"Tickle J","year":"2012","journal-title":"Br J Community Nurs"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2016.25.5.290"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13515"},{"issue":"2","key":"e_1_2_10_14_1","first-page":"163","article-title":"The accuracy of venous leg ulcer prognostic models in a wound care system","volume":"12","author":"Margolis DJ","year":"2004","journal-title":"Int J Tissue Repair Regener"},{"issue":"9","key":"e_1_2_10_15_1","first-page":"267","article-title":"Wounds measured from digital photographs using photodigital planimetry software: validation and rater reliability","volume":"23","author":"Wendelken ME","year":"2011","journal-title":"Wounds Compend Clin Res Pract"},{"key":"e_1_2_10_16_1","first-page":"95","article-title":"Parameter for measurement of wound closure","volume":"3","author":"Gilman T","year":"1990","journal-title":"Wounds Compend Clin Res Pract"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2014.23.3.105"},{"issue":"15","key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.12968\/bjon.2015.24.Sup15.S12","article-title":"Managing the problem of excess exudate","volume":"24","author":"Moore Z","year":"2015","journal-title":"Br J Nurs (Mark Allen Publishing)"},{"issue":"4","key":"e_1_2_10_19_1","first-page":"56","article-title":"Understanding undisturbed wound healing in clinical practice \u2010 a global survey of healthcarefhealthcare professionals","volume":"15","author":"Davies P","year":"2019","journal-title":"Wounds UK"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.13913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iwj.13913","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.13913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T18:49:25Z","timestamp":1692730165000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.13913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":18,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/iwj.13913"],"URL":"https:\/\/doi.org\/10.1111\/iwj.13913","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"2021-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}