{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:38:07Z","timestamp":1790127487655,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epidermolysis bullosa (EB) is an inherited disorder characterised by skin fragility and the appearance of blisters and wounds. Patient wounds are often colonised or infected with bacteria, leading to impaired healing, pain and high risk of death by sepsis. Little is known about the impact of bacterial composition and susceptibility in wound resolution, and there is a need for longitudinal studies to understand healing outcomes with different types of bacterial colonisation. A prospective longitudinal study of 70 wounds from 15 severe EB patients (Junctional and Recessive Dystrophic EB) from Chile. Wounds were selected independently of their infected status. Wound cultures, including bacterial species identification, composition and <jats:italic>Staphylococcus aureus<\/jats:italic> (SA) antibiotic susceptibility were registered. Wounds were separated into categories according to their healing capacity, recognising chronic, and healing wounds. Hundred\u2010one of the 102 wound cultures were positive for bacterial growth. From these, 100 were SA\u2010positive; 31 were resistant to Ciprofloxacin (31%) and only seven were methicillin\u2010resistant SA (7%). Ciprofloxacin\u2010resistant SA was found significantly predominant in chronic wounds (**<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). Interestingly, atoxigenic <jats:italic>Corynebacterium diphtheriae<\/jats:italic> (CD) was identified and found to be the second most abundant recovered bacteria (31\/101), present almost always in combination with SA (30\/31). CD was only found in Recessive Dystrophic EB patients and not related to wound chronicity. Other less frequent bacterial species found included <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, <jats:italic>Streptococus<\/jats:italic> spp. and <jats:italic>Proteus<\/jats:italic> spp. Infection was negatively associated with the healing status of wounds.<\/jats:p>","DOI":"10.1111\/iwj.13922","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T05:00:46Z","timestamp":1660194046000},"page":"774-783","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Longitudinal study of wound healing status and bacterial colonisation of <i>Staphylococcus aureus<\/i> and <i>Corynebacterium diphtheriae<\/i> in epidermolysis bullosa patients"],"prefix":"10.1111","volume":"20","author":[{"given":"Ignacia","family":"Fuentes","sequence":"first","affiliation":[{"name":"DEBRA Chile  Santiago Chile"},{"name":"Centro de Gen\u00e9tica y Gen\u00f3mica, Facultad de Medicina Cl\u00ednica Alemana 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