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Moreover, cutaneous manifestations have been reported in 0.2% to 20.4% of cases. Early diagnosis of COVID\u201019 leads to a better prognosis; knowledge of its cutaneous manifestations is one way that may help fulfil this goal. In this review, PubMed and Medline were searched with the terms \u201cdermatology\u201d, \u201cskin\u201d and \u201ccutaneous\u201d, each in combination with \u201cSARS\u2010CoV\u20102\u201d or \u201cCOVID\u201019\u201d. All articles, including original articles, case reports, case series and review articles published from the emergence of the disease to the time of submission, were included. In this comprehensive narrative review, we tried to provide an analysis of the cutaneous manifestations associated with COVID\u201019, including maculopapular rash, urticaria, Chilblain\u2010like, vesicular lesions, livedo reticularis and petechiae in asymptomatic\/symptomatic COVID\u201019 patients that might be the first complication of infection after respiratory symptoms. Immune dysregulation, cytokine storms, side effects of antiviral drugs, environmental conditions and high\u2010dose intravenous immunoglobulin (IVIG) therapy might be involved in the pathogenesis of the cutaneous manifestations in COVID\u201019 patients. Therefore, knowledge of cutaneous COVID\u201019 manifestations might be vital in achieving a quick diagnosis in some COVID\u201019 patients, which would help control the pandemic. Further research is very much warranted to clarify this issue.<\/jats:p>","DOI":"10.1111\/iwj.13933","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T06:24:58Z","timestamp":1665728698000},"page":"871-879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A comprehensive narrative review of the cutaneous manifestations associated with <scp>COVID<\/scp>\u201019"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7282-3538","authenticated-orcid":false,"given":"Nasir","family":"Arefinia","sequence":"first","affiliation":[{"name":"Department of Bacteriology and Virology, School of Medicine Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohreh al\u2010sadat","family":"Ghoreshi","sequence":"additional","affiliation":[{"name":"Department of biochemistery, School of Medicine Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Hossein","family":"Alipour","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Virology, School of Medicine Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behzad","family":"Iranmanesh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Afzalipour Hospital, Afzalipour Faculty of Medicine Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niloofar","family":"Mehrolhasani","sequence":"additional","affiliation":[{"name":"Pathology and Stem Cell Research Center, Dermatopathology Department, Afzalipour Teaching Hospital Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simin","family":"Shamsi\u2010Meymandi","sequence":"additional","affiliation":[{"name":"Pathology and Stem Cell Research Center, Dermatopathology Department, Afzalipour Teaching Hospital Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamal","family":"Sarvari","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Virology, School of Medicine Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Gastroenterohepatology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2020.1309"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19264"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2020.104395"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2608.200681"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01175-20"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.2687"},{"key":"e_1_2_12_9_1","article-title":"COVID\u201019 \u2010 guidance for management of children admitted to hospital | RCPCH","author":"Health Policy Team","year":"2020","journal-title":"Rcpch 2020"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(20)30651\u20104"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098\u2010020\u201003322\u2010y"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2020.10.020"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249\u2010020\u201000662\u2010x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.05.087"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102433"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S261304"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010020\u201005965\u20101"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30686\u20103"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100433"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1236520"},{"issue":"6","key":"e_1_2_12_21_1","first-page":"726","article-title":"The generalized rash: Part I. 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