{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T08:02:24Z","timestamp":1791619344376,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This meta\u2010analysis aims to systemically evaluate the efficacy of vacuum sealing drainage (VSD) combined with autologous platelet\u2010rich plasma (PRP) in the treatment of diabetic foot ulcers (DFU). The China HowNet, China Biomedical Literature, VIP periodical resource integration service platform, Wanfang, Embase, Cochrane Central, and PubMed databases were retrieved using the computer. The retrieval period was up to July 2021. Randomised controlled trials on VSD combined with PRP in the treatment of DFU were collected. Those trials that met the inclusion criteria were included for meta\u2010analysis using RevMan 5.3 software. A total of 13 articles were included. In the trial group, 477 patients with DFU were treated with VSD combined with PRP, while in the control group, 482 patients with DFU were treated with conventional dressings and\/or VSD. The meta\u2010analysis showed that, compared with the control group, VSD combined with PRP has significant advantages in shortening healing time (standardised mean difference [SMD]\u00a0=\u00a0\u22120.87, 95% confidence interval [CI]: \u22121.07 to \u22120.67, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.00001), improving ulcer healing rates (odds ratio\u00a0=\u00a04.01, 95% CI: 2.95\u2009~\u20095.46, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.00001), and reducing hospital stays (mean difference\u00a0=\u00a0\u221215.29, 95% CI: \u221216.05 to \u221214.54, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.00001), but the differences in dressing change times (SMD\u00a0=\u00a0\u22121.27, 95% CI: \u22122.71 to 0.17, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.08) and hospitalisation expenses (SMD\u00a0=\u00a0\u22120.16, 95% CI: \u221213.40 to 13.07, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.98) were not statistically significant. VSD combined with autologous PRP has good curative efficacy in the treatment of DFU and is a better treatment option. However, this treatment is limited in patients with platelet dysfunction, thrombocytopenia, leukaemia, and poor general condition.<\/jats:p>","DOI":"10.1111\/iwj.13956","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T08:40:06Z","timestamp":1663317606000},"page":"1033-1041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A meta\u2010analysis on the efficacy of vacuum sealing drainage combined with autologous platelet\u2010rich plasma in the treatment of Grade 2 and Grade 3 diabetic foot ulcers"],"prefix":"10.1111","volume":"20","author":[{"given":"Xiao\u2010Ling","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Endocrinology The First Hospital of Nanchang (The Third Affiliated Hospital of Nanchang University)  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9017-1131","authenticated-orcid":false,"given":"Ling","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Hospital of Nanchang (The Third Affiliated Hospital of Nanchang University)  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Hospital of Nanchang (The Third Affiliated Hospital of Nanchang University)  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Hospital of Nanchang (The Third Affiliated Hospital of Nanchang University)  Nanchang Jiangxi 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