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Clinical trials testing innovative approaches to improve healing outcomes are critically needed because standard therapies are often ineffective. However, patients with VLUs frequently have multiple physical, emotional and socioeconomic challenges that can negatively impact their decision to enrol in a clinical trial. To benefit clinical researchers and ultimately the community of patients with chronic wounds, this paper describes the monitoring and modification of recruitment strategies in an ongoing clinical trial testing effects of omega\u20103 fatty acid oral supplementation on VLU healing in ageing adults (n\u00a0=\u00a0208). Multiple modifications over time in this study have targeted participation barriers identified through data monitoring and include expanding inclusion criteria, adding recruitment sites, enhancing communication methods, and meeting patients' transportation needs. Recruitment activities from January 2019 to June 2022 have resulted in 57 participants (mean age: 63.7\u2009years). Overall, the recruitment rate is 42.5% of patients contacted during face\u2010to\u2010face visits. Overcoming barriers to participation is key to helping patients with VLUs interested in research enrol in clinical trials aiming to improve healing outcomes in this vulnerable population.<\/jats:p>","DOI":"10.1111\/iwj.13957","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T08:41:07Z","timestamp":1663231267000},"page":"1042-1052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Monitoring and modifying recruitment and retention strategies for an ongoing randomised clinical trial with venous leg ulcer patients: Overcoming barriers to participation"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3089-4928","authenticated-orcid":false,"given":"Jodi Christine","family":"McDaniel","sequence":"first","affiliation":[{"name":"College of Nursing The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie Ann","family":"Rausch","sequence":"additional","affiliation":[{"name":"School of Nursing Indiana University Fort Wayne  Fort Wayne Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina Rose","family":"McGowan","sequence":"additional","affiliation":[{"name":"College of Nursing The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.04.049"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2014.903258"},{"issue":"2","key":"e_1_2_10_4_1","first-page":"105","article-title":"Epidemiology of chronic venous disorders in geographically diverse populations: results from the Vein Consult Program","volume":"31","author":"Rabe E","year":"2012","journal-title":"Int Angiol"},{"key":"e_1_2_10_5_1","unstructured":"U.S. Census Bureau.Projected Population for the United States by Age Group and Alternative Immigration Scenario: 2020 to 2060 (NP2017\u2010D). 2017. 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