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Seventy four participants with CVLU who received weekly sharp debridement were recruited from a wound care clinic during the 8\u2010week study period. To examine associations among wound CRP, MMPs, pain, fatigue, and wound healing trajectory over time, we calculated Bayes factors (BF) based on a linear mixed model. The mean age of participants was 71.8 (SD\u00a0=\u00a09.8) and the mean wound area was 2278\u2009mm<jats:sup>2<\/jats:sup> (SD\u00a0=\u00a07085\u2009mm<jats:sup>2<\/jats:sup>) at baseline. Higher fatigue was strongly associated with higher MMPs (BF\u00a0=\u00a09, 95% HDI: [\u2212.05, .43]), lower CRP (BF\u00a0=\u00a011, 95% HDI: [\u2212.02, .002]), and large areas of wound (BF\u00a0=\u00a020, 95% HDI: [\u2212.001, .01]). Higher CRP and MMPs activity in wound exudate and higher fatigue were associated with a larger wound area. To facilitate wound healing, clinicians need to utilise the multifactorial approach, which includes wound treatment and management of symptoms such as pain and fatigue, because of the molecular and psycho\u2010behavioural factors involved in wound healing.<\/jats:p>","DOI":"10.1111\/iwj.13966","type":"journal-article","created":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T06:29:52Z","timestamp":1664605792000},"page":"1098-1111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The association of wound factors and symptoms of fatigue and pain with wound healing in chronic venous leg ulcers"],"prefix":"10.1111","volume":"20","author":[{"given":"Junglyun","family":"Kim","sequence":"first","affiliation":[{"name":"College of Nursing Chungnam National University College of Nursing  Daejeon South Korea"},{"name":"Department of Biobehavioral Nursing Science University of Florida College of Nursing  Gainesville 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