{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:53:59Z","timestamp":1787014439113,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Because the application of intracavitary electrocardiogram (IC\u2010ECG)\u2010guided peripherally inserted central catheter (PICC) in the treatment of neonates is controversial in terms of phlebitis reduction compared with traditional X\u2010ray positioning technique, a systematical evaluation is needed on the impact of IC\u2010ECG on this common complication following PICC. Literature retrieval was conducted on large databases including PubMed, Google Scholar, Cochrane library, and CNKI. Randomised controlled trials (RTCs) of intracavitary electrocardiogram\u2010guided peripherally inserted central catheter tip placement in the treatment of neonates up to July 7, 2022, were collected. Then indicators of included studies were compared and analysed by two researchers. Meta\u2010analysis was performed on the STATA 17.0 software. After excluding invalid trials, 11 out of 316 randomised controlled trials were included for further analysis. Meta\u2010analysis results showed that compared with the control group, IC\u2010ECG\u2010guided PICC could decrease the incidence of phlebitis (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u20090.00%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u20090.76, OR\u00a0=\u00a00.33, 95% CI 0.19\u20130.56) and that no significant difference was observed between preterm neonates and term neonates (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u20090.74). Meanwhile, total complications were decreased in neonates (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u20090.00%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u20090.00 OR\u00a0=\u00a00.23, 95% CI 0.16\u20130.33). IC\u2010ECG\u2010guided PICC could also improve the accuracy of optimal tip location (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u20090.00%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u20090.53, OR\u00a0=\u00a05.37, 95% CI 3.80\u20137.59). IC\u2010ECG\u2010guided PICC could achieve reduced phlebitis incidence and total complications in the treatment of neonates, as well as increased accuracy of optimal tip location, no matter if those neonates were preterm or not. This study was registered in inplasy.com with No. INPLASY202280012 (DOI: 10.37766\/inplasy2022.8.0012).\n                  <\/jats:p>","DOI":"10.1111\/iwj.13971","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T19:44:09Z","timestamp":1665517449000},"page":"1130-1138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of peripherally inserted central venous catheter\u2010associated phlebitis in neonate guided by intracavitary electrocardiogram: A systematic review and meta\u2010analysis of randomised controlled trials"],"prefix":"10.1111","volume":"20","author":[{"given":"Wenyi","family":"Gan","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, West China Hospital, Sichuan University\/West China School of Nursing Sichuan University  Chengdu 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