{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:29:23Z","timestamp":1790314163401,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Negative pressure wound therapy (NPWT) with or without instillation has been extensively applied for patients with multiple wound types. Whether NPWT with instillation is superior to NPWT alone is not known. This study aims to compare the efficacy between negative pressure wound therapy with instillation (NPWTi) and standard negative pressure wound therapy for wounds. The authors searched for randomised controlled trials (RCTs) in PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials investigating clinical outcomes of negative pressure wound therapy with instillation vs standard negative pressure wound therapy for wounds. The registration number (protocol) on PROSPERO is CRD42022287178. Eight RCTs involved 564 patients met the inclusion criteria and were included finally. NPWTi showed a significant fewer surgeries and dressing changes (RR and 95% CI, \u22129.31 [\u221217.54, \u22121.08], <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and smaller wound area after treatment (RR and 95% CI, \u22129.31 [\u221217.54, \u22121.08], <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) compared with NPWT. No significant difference was observed on healing rate, time to heal, length of stay, dehiscence, reinfection, reoperation and readmission between NPWTi and NPWT. The addition of instillation to NPWT could improve clinical outcomes regarding the number of surgeries and dressing changes, and wound area after treatment in patients with multiple wound types. However, because of the heterogeneity these conclusions still need to be further validated by more well\u2010designed RCTs with large sample sizes.<\/jats:p>","DOI":"10.1111\/iwj.13989","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T09:29:23Z","timestamp":1671096563000},"page":"1739-1749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical outcomes of negative pressure wound therapy with instillation vs standard negative pressure wound therapy for wounds: A meta\u2010analysis of randomised controlled trials"],"prefix":"10.1111","volume":"20","author":[{"given":"Guoqi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatric The First Medical Center of Chinese PLA General Hospital  Beijing China"},{"name":"Senior Department of Pediatric The Seventh Medical Center of Chinese PLA General Hospital  Beijing China"},{"name":"National Clinical Research Center for Orthopedics, Sports Medicine &amp; Rehabilitation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Medical Supplies Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoxiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Orthopedics, Sports Medicine &amp; Rehabilitation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Hainan Hospital of Chinese PLA General Hospital  Sanya China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daohong","family":"Liu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Orthopedics, Sports Medicine &amp; Rehabilitation  Beijing China"},{"name":"Senior Department of Orthopedics The Fourth Medical Center of PLA General Hospital  Beijing China"},{"name":"Department of Orthopedics The Eighth Medical Center of PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"issue":"12","key":"e_1_2_9_2_1","first-page":"394","article-title":"Closure under reduced atmospheric pressure of extensive wounds","volume":"80","author":"Redon H","year":"1954","journal-title":"Mem Acad 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