{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T06:32:29Z","timestamp":1767162749487,"version":"build-2238731810"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The adjuvant effectiveness of nalbuphine in context of brachial plexus block (BPB) in patients undergoing upper\u2010limb orthopaedic trauma surgery has remained uncertain. The purpose of this meta\u2010analysis was to evaluate the analgesic benefit of mixing nalbuphine into local anaesthetics in BPB for wound pain from upper\u2010limb trauma surgery. Primary outcome was the duration of analgesia. Seventeen trials (1104 patients) were analysed. Patients receiving nalbuphine have an increased weighted mean difference (WMD) 95% confidence interval of the duration of analgesia by 186.91\u2009minutes (133.67 to 240.16) (\n                    <jats:italic>P\u2009&lt;<\/jats:italic>\n                    \u00a00.001). Compared to placebo, nalbuphine shorten the onset time of sensory and motor block by WMD of 2.59 (1.27 to 3.92) and 3.06\u2009minutes (1.65 to 4.48) (\n                    <jats:italic>P\u2009&lt;<\/jats:italic>\n                    \u00a00.001), respectively. Meanwhile, nalbuphine prolonged the durations of sensory and motor block (\n                    <jats:italic>P\u2009&lt;<\/jats:italic>\n                    \u00a00.001). Qualitative and quantitative synthesis revealed no differences with regard to the outcomes related to side\u2010effects. There is moderate\u2010quality evidence that the addition of nalbuphine to local anaesthetics for BPB in patients undergoing upper\u2010limb orthopaedic trauma surgery significantly prolongs the duration of analgesia, while preserving a similar safety\u2010profile compared with local anaesthetics alone. However, these benefits should be further weighed against nalbuphine\u2010related neurological safety in future studies.\n                  <\/jats:p>","DOI":"10.1111\/iwj.14002","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T02:42:30Z","timestamp":1667529750000},"page":"1476-1490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["RETRACTED: A meta\u2010analysis showing the quantitative evidence base of perineural nalbuphine for wound pain from upper\u2010limb orthopaedic trauma surgery"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3853-8159","authenticated-orcid":false,"given":"Wei","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, West China Hospital Sichuan University  Chengdu 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