{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:53:07Z","timestamp":1787014387211,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Liposomal bupivacaine (LB) has consistently been considered a potential analgesic for surgical wound infiltration. However, the evidence of its analgesic effectiveness remains unclear. In this meta\u2010analysis, we attempted to identify the potential clinical role of LB wound infiltration in different surgical procedures. Randomised controlled trials (RCTs) comparing LB with non\u2010liposomal local anaesthetics and placebos were retrieved from six electronic databases. The primary outcome was cumulative morphine equivalent consumption within 24, 48, and 72\u2009hours after surgery. Approximately 2659 patients from 22 studies were included in the meta\u2010analysis. Compared to the control, LB\u2010wound infiltration did not reduce the postoperative morphine consumption at 24\u2009hours (weighted mean difference [WMD], \u22120.60\u2009mg; 97.5% confidence interval [CI], \u22122.78 to 1.59\u2009mg;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.54), 48\u2009hours (WMD, \u22121.00\u2009mg; 97.5% CI, \u22123.23 to 1.24;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.32) or 72\u2009hours (WMD, 0.50\u2009mg; 97.5% CI, \u22120.67 to 1.67;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.33). Similarly, secondary outcome analysis did not reveal any additional benefits of LB in any other pain\u2010related outcomes. LB was not associated with any adverse effects. Overall, LB does not appear to improve the postoperative analgesic, rehabilitation, or safety outcomes. Current evidence does not support the routine use of LB for wound infiltration following surgical procedures.\n                  <\/jats:p>","DOI":"10.1111\/iwj.14015","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T05:14:05Z","timestamp":1667884445000},"page":"1591-1608","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["RETRACTED: The effect of liposomal bupivacaine for surgical wound infiltration: A meta\u2010analysis of randomised controlled trials"],"prefix":"10.1111","volume":"20","author":[{"given":"Hua","family":"Jiang","sequence":"first","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Ma","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Dong","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ye","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2020-102395"},{"issue":"2","key":"e_1_2_10_3_1","first-page":"CD011419","article-title":"Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain","volume":"2","author":"Hamilton TW","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2021.0163"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13517"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2022.110918"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.0898"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2021-067325","article-title":"Effect of dexamethasone as an analgesic adjuvant to multimodal pain treatment after total knee arthroplasty: randomised clinical trial","volume":"376","author":"Gasbjerg KS","year":"2022","journal-title":"BMJ"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2020-101593"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2020.110098"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003658"},{"issue":"5","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1136\/rapm-2021-103349","article-title":"Comparing liposomal bupivacaine plus bupivacaine to bupivacaine alone in interscalene blocks for rotator cuff repair surgery: a randomized clinical trial","volume":"47","author":"Flaherty JM","year":"2022","journal-title":"Reg Anesth Pain Med"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004111"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2021.110640"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2021.110527"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.07.017"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2020.100115"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.0753"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000000855"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7454.1490"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003651"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-012-0043-z"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2020-101917"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2020-101995"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2021.0067"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e318232d4c1"},{"key":"e_1_2_10_30_1","unstructured":"NCT00485433.Dose\u2010ranging study for postoperative analgesia in subjects undergoing primary unilateral inguinal hernia repair.2007.https:\/\/ClinicalTrials.gov\/show\/NCT00485433"},{"key":"e_1_2_10_31_1","unstructured":"NCT00529126.Phase 2 dose\u2010ranging study of SKY0402 for prolonged postoperative analgesia in subject undergoing hemorrhoidectomy.2007.https:\/\/ClinicalTrials.gov\/show\/NCT00529126"},{"key":"e_1_2_10_32_1","unstructured":"NCT00744848.Study to evaluate postoperative analgesia in subjects undergoing hemorrhoidectomy.2008.https:\/\/ClinicalTrials.gov\/show\/NCT00744848"},{"key":"e_1_2_10_33_1","unstructured":"NCT00890721. Study of pain control in hemorrhoidectomy.2009.https:\/\/ClinicalTrials.gov\/show\/NCT00890721"},{"key":"e_1_2_10_34_1","unstructured":"NCT01203644.Evaluation of the safety efficacy and pharmacokinetics of SKY0402 in subjects undergoing Inguinal Hernia repair.2004.https:\/\/ClinicalTrials.gov\/show\/NCT01203644"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2016.11.002"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbcr\/irab129"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-011-0052-y"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481207800540"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2018.11.005"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.09.029"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2014.0769"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000648"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2019.06.004"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.07.001"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002649"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002375"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.02.011"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2016.09.042"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2019.04.046"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2017.09.013"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2020-102427"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003630"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2019.07.012"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/467429"}],"updated-by":[{"DOI":"10.1111\/iwj.70563","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000}}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.14015","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iwj.14015","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.14015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T22:49:23Z","timestamp":1745016563000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.14015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,8]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/iwj.14015"],"URL":"https:\/\/doi.org\/10.1111\/iwj.14015","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,8]]},"assertion":[{"value":"2022-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}