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The analysis was undertaken through the Secure Anonymised Information Linkage Databank, which brings together population\u2010scale, individual\u2010level anonymised linked data from a wide range of sources, including 80% of primary care general practices within Wales (population coverage ~3.2 million). The data covered a 20\u2010year period from 1999 to 2019. All patients linked to the relevant codes were tracked through primary care settings, recording the number of general practice visits (number of days with an event recorded) and number of in\u2010patient stays. Resources were valued in monetary terms (\u00a3 sterling), with costs determined from national published sources of unit costs. These resources were then extrapolated out to reflect UK NHS costs. This is the first attempt to estimate the financial burden of cellulitis using routine data sources on a national scale. The estimated direct annual costs to the Welsh NHS (\u00a328\u2009554\u2009338) are considerable. In\u2010Patient events and length of stay costs are the main cost drivers, with annual Welsh NHS estimates of \u00a319\u2009664\u2009126 with primary care events costing \u00a38\u2009890\u2009212. Initiatives to support patients and healthcare professionals in identifying early signs\/risks of cellulitis, improve the accuracy of initial diagnosis, prevent cellulitis recurrence, and improve evidence\u2010based treatment pathways would result in major financial savings, to both the Welsh and UK NHS. In light of these findings, Wales has developed the innovative National Lymphoedema cellulitis Improvement Programme to address these burdens; providing a proactive model of cellulitis care.<\/jats:p>","DOI":"10.1111\/iwj.14088","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T12:30:10Z","timestamp":1673958610000},"page":"2129-2140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evaluating the cost of managing patients with cellulitis in Wales, <scp>UK<\/scp>: A 20\u2010year population\u2010scale study"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7993-0179","authenticated-orcid":false,"given":"Ioan","family":"Humphreys","sequence":"first","affiliation":[{"name":"Health and Wellbeing Academy, School of Health and Social Care, Faculty of Medicine, Health and Life Sciences Swansea University  Swansea UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0814-0801","authenticated-orcid":false,"given":"Ashley","family":"Akbari","sequence":"additional","affiliation":[{"name":"Population Data Science, Health Data Research UK, Swansea University Medical School, Faculty of Medicine, Health and Life Sciences Swansea University  Swansea UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rowena","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Population Data Science, Health Data Research UK, Swansea University Medical School, Faculty of Medicine, Health and Life Sciences Swansea University  Swansea UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dave","family":"Graham\u2010Woollard","sequence":"additional","affiliation":[{"name":"Lymphoedema Network Wales Swansea Bay University Health Board  Swansea UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Morgan","sequence":"additional","affiliation":[{"name":"Lymphoedema Network Wales Swansea Bay University Health Board  Swansea UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhian","family":"Noble\u2010Jones","sequence":"additional","affiliation":[{"name":"Lymphoedema Network Wales Swansea Bay University Health Board  Swansea UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Gabe\u2010Walters","sequence":"additional","affiliation":[{"name":"Lymphoedema Network Wales Swansea Bay University Health Board  Swansea UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Thomas","sequence":"additional","affiliation":[{"name":"Lymphoedema Network Wales Swansea Bay University Health Board  Swansea UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19803"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7198.1591"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2021.04.009"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1307232"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19803"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/rnj.171"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01648.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-014-0422-0"},{"issue":"2","key":"e_1_2_10_10_1","first-page":"P38","article-title":"cellulitis and lymphoedema: a vicious cycle","volume":"4","author":"Al\u2010Niaimi F","year":"2009","journal-title":"J Lymphoed"},{"key":"e_1_2_10_11_1","unstructured":"NHS Digital.Hospital Admitted Patient Care Activity 2018\u201319.2019.Available at:https:\/\/digital.nhs.uk\/data-and-information\/publications\/statistical\/hospital-admitted-patient-care-activity\/2018-19."},{"key":"e_1_2_10_12_1","unstructured":"SAIL Databank.https:\/\/saildatabank.com\/."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472\u20106947\u20109\u20103"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-9-157"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","unstructured":"PEDW (Patient Episode data base Wales) data (19\u201020) down accessed Sept 2021. 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