{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T21:15:37Z","timestamp":1774559737453,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771933"],"award-info":[{"award-number":["81771933"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study explored the effect of perioperative use of low\u2010dose dexamethasone on inflammatory factors in drainage fluid and wound healing after thyroid surgery. In the prospective, double\u2010blinded, randomised controlled study, adults who underwent elective thyroidectomy received 0.1\u00a0mg\/kg of intravenous dexamethasone or a matching volume of placebo (saline) after induction of general anaesthesia. The primary outcome was IL6 and IL10 concentration in drainage at 24\u2009hours postoperative. The secondary endpoint was the SBSES (modified Stony Brook Scar Evaluation Scale) total score at 1\u00a0week postoperative. From 8 July to 17 December 2020, 64 patients (mean [SD] age, 40.42 [9.52]; 13 males [20.31%]) were recruited, received operation, and completed the 1\u2010month follow\u2010up. Inflammatory factors in drainage did not differ between the two groups but only had significant differences at different timepoint. The dexamethasone group patients had a higher SBSES total score at 1\u00a0week after the treatment but, without statistical significance (dexamethasone vs placebo: 3.13\u2009\u00b1\u20091.24 vs 2.97\u2009\u00b1\u20090.93, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.571). The dexamethasone group patients had a higher SBSES total score (dexamethasone vs placebo: 3.103\u2009\u00b1\u20091.148 vs 2.868\u2009\u00b1\u20090.827, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.011) and colour score (dexamethasone vs placebo: 0.603\u2009\u00b1\u20090.493 vs 0.412\u2009\u00b1\u20090.496, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.026) at 1\u2010week follow\u2010up than the placebo group patients. Preoperative single small\u2010dose intravenous dexamethasone did not show to improve wound healing quality nor reduce incision inflammation but may release pain, and reduce tissue angiogenesis, and thus the scar redness.<\/jats:p>","DOI":"10.1111\/iwj.14090","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T15:52:15Z","timestamp":1677685935000},"page":"2141-2150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of low\u2010dose dexamethasone on inflammatory factors in drainage fluid and wound healing after thyroid surgery during perioperative period"],"prefix":"10.1111","volume":"20","author":[{"given":"Xuemei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Shanghai Tenth People's Hospital, Tongji University School of Medicine  Shanghai China"},{"name":"Department of Anesthesiology Shanghai Jiaotong University Affiliated Shanghai Sixth People's Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Shanghai Jiaotong University Affiliated Shanghai Sixth People's Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7966-3637","authenticated-orcid":false,"given":"Xiaojun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Ruijin Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8586-8463","authenticated-orcid":false,"given":"Quanhong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Shanghai Jiaotong University Affiliated Shanghai Sixth People's Hospital  Shanghai 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