{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:42:32Z","timestamp":1790775752897,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diabetic foot ulcer (DFU) is a major cause of morbidity, non\u2010traumatic lower limb amputation in diabetic patients and a high\u2010cost burden on the healthcare system. New therapeutic products are increasingly tested. Platelet\u2010rich plasma (PRP) and human platelet lysate (hPL) are reported to be useful. This trial was conducted to test whether the healing effect of hPL in chronic DFU was due to plasma or platelet lysates in a prospective double\u2010blind design. Autologous PRP was obtained from citrated blood, lysed, and used as drug 1 (active product). The platelet\u2010poor plasma (PPP) was used as a drug 2 (placebo). Ten patients were enrolled in arm 1 and 9 in arm 2. The drugs were injected perilesionally every 2\u2009weeks for a total of sixinjections. Adverse events were recorded until Week 14. The DFUs were scored per the Texas and Wegner systems. No patient showed any major adverse events. Some reported local pain post\u2010injection. Wound healing was achieved in the hPL group in 9\/10 of patients at a mean of 35.1\u2009days. In the PPP group, no patient had healed by Day 84. The difference was statistically significant at\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.00001. We conclude that autologous hPL is safe and highly effective in healing chronic DFU and is superior to autologous PPP.\n                  <\/jats:p>","DOI":"10.1111\/iwj.14186","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T07:24:26Z","timestamp":1683185066000},"page":"3116-3122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Perilesional injections of human platelet lysate versus platelet poor plasma for the treatment of diabetic foot ulcers: A\n                    <scp>double\u2010blinded<\/scp>\n                    prospective clinical trial"],"prefix":"10.1111","volume":"20","author":[{"given":"Hussam","family":"Alhawari","sequence":"first","affiliation":[{"name":"School of Medicine, Department of Internal Medicine The University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6088-8783","authenticated-orcid":false,"given":"Hanan","family":"Jafar","sequence":"additional","affiliation":[{"name":"Cell Therapy Center The University of Jordan  Amman Jordan"},{"name":"Department of Anatomy and Histology, School of Medicine The University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Al Soudi","sequence":"additional","affiliation":[{"name":"School of Medicine University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena Abu","family":"Ameereh","sequence":"additional","affiliation":[{"name":"Cell Therapy Center The University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maram","family":"Fawaris","sequence":"additional","affiliation":[{"name":"Cell Therapy Center The University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohanad","family":"Saleh","sequence":"additional","affiliation":[{"name":"Cell Therapy Center The University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safwan","family":"Aladwan","sequence":"additional","affiliation":[{"name":"Faculty of Allied Medical Sciences Al\u2010Ahliyya Amman University  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidal","family":"Younes","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine The University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdalla","family":"Awidi","sequence":"additional","affiliation":[{"name":"Cell Therapy Center The University of Jordan  Amman Jordan"},{"name":"Department of Internal Medicine Hematology\u2010Oncology, School of Medicine The University of Jordan  Amman Jordan"},{"name":"Department of 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