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DFU therapy is difficult and involves long\u2010term interdisciplinary collaboration, causing patients physical and emotional pain and increasing medical costs. With a rising number of diabetes patients, it is vital to figure out the causes and treatment techniques of DFU in a precise and complete manner, which will assist alleviate patients' suffering and decrease excessive medical expenditure. Here, we summarised the characteristics and progress of the physical therapy methods for the DFU, emphasised the important role of appropriate exercise and nutritional supplementation in the treatment of DFU, and discussed the application prospects of non\u2010traditional physical therapy such as electrical stimulation (ES), and photobiomodulation therapy (PBMT) in the treatment of DFU based on clinical experimental records in <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>.<\/jats:p>","DOI":"10.1111\/iwj.14196","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T05:44:28Z","timestamp":1682401468000},"page":"3417-3434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Physical therapy in diabetic foot ulcer: Research progress and clinical application"],"prefix":"10.1111","volume":"20","author":[{"given":"Hao","family":"Huang","sequence":"first","affiliation":[{"name":"School of Pharmacy Bengbu Medical College  Bengbu Anhui China"},{"name":"Shanghai Skin Disease Hospital, School of Medicine Tongji University  Shanghai China"},{"name":"Department of Pharmacy Third Affiliated Hospital of Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rujuan","family":"Xin","sequence":"additional","affiliation":[{"name":"Shanghai Skin Disease Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy Bengbu Medical College  Bengbu Anhui China"},{"name":"Shanghai Skin Disease Hospital, School of Medicine Tongji University  Shanghai 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