{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:14:12Z","timestamp":1793258052202,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T00:00:00Z","timestamp":1685750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072169"],"award-info":[{"award-number":["82072169"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272279"],"award-info":[{"award-number":["82272279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deep sternal wound infection (DSWI) is a relatively complex wound in wound reconstruction surgery. Because plastic surgeons deal with DSWI patients late. The primary healing (healing by first intention) after reconstruction of DSWI is restricted by many preoperative risk factors. The purpose of this study is to explore and analyse the risk factors of primary healing failure in patients with DSWI treated with platelet\u2010rich plasma (PRP) and negative pressure trauma therapy (NPWT). 115 DSWI patients treated with the PRP and NPWT (PRP\u2009+\u2009NPWT) modality were retrospectively (2013\u20102021) analysed. They were divided into two groups according to primary healing results after the first PRP\u2009+\u2009NPWT treatment. Univariate and multivariate analyses were used to compare the data of the two groups to find out the risk factors and their optimal cut\u2010off values were identified by ROC analysis. The primary healing results, debridement history, wound size, sinus, osteomyelitis, renal function, bacterial culture, albumin (ALB), platelet (PLT) between the two groups were significantly different (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Binary logistic regression showed that osteomyelitis, sinus, ALB and PLT were the risk factors affecting primary healing outcomes (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). ROC analysis showed that AUC for ALB in the non\u2010primary healing group was 0.743 (95% CI: 0.650\u20100.836, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and its optimal cutoff value of 31\u2009g\/L was associated with primary healing failure with a sensitivity of 96.9% and specificity of 45.1%. AUC for PLT in the non\u2010primary healing group was 0.670 (95% CI: 0.571\u2009~\u20090.770, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) its optimal cutoff value of 293\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L was associated with primary healing failure with a sensitivity of 72.5% and specificity of 56.3%. In the cases included in this study, the success rate of primary healing of DSWI treated with PRP\u2009+\u2009NPWT was not affected by the most common preoperative risk factors for wound non\u2010union. It is indirectly confirmed that PRP\u2009+\u2009NPWT is an ideal treatment. However, it should be noted that it will still be adversely affected by sinus osteomyelitis, ALB and PLT. The patients need to be carefully evaluated and corrected before reconstruction.<\/jats:p>","DOI":"10.1111\/iwj.14216","type":"journal-article","created":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T06:58:26Z","timestamp":1685775506000},"page":"3457-3466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A study on the preoperative risk factors for primary healing failure in the reconstruction of deep sternal wound infection with platelet\u2010rich plasma and negative pressure trauma therapy"],"prefix":"10.1111","volume":"20","author":[{"given":"Yaoyao","family":"Song","sequence":"first","affiliation":[{"name":"Department of Burns and Plastic Surgery Fourth Medical Center of Chinese PLA General Hospital, (PLA:People's Liberation Army)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanli","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery Fourth Medical Center of Chinese PLA General Hospital, (PLA:People's Liberation Army)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery Fourth Medical Center of Chinese PLA General Hospital, (PLA:People's Liberation Army)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery Fourth Medical Center of Chinese PLA General Hospital, (PLA:People's Liberation Army)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery Fourth Medical Center of Chinese PLA General Hospital, (PLA:People's Liberation Army)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery Fourth Medical Center of Chinese PLA General Hospital, (PLA:People's Liberation Army)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery Fourth Medical Center of Chinese PLA General Hospital, (PLA:People's Liberation Army)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery Fourth Medical Center of Chinese PLA General Hospital, (PLA:People's Liberation Army)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huageng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Burns and 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