{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:09:14Z","timestamp":1767164954717,"version":"build-2238731810"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to evaluate the effectiveness of dexmedetomidine as an adjuvant to local wound infiltration anaesthesia in reducing surgical site wound pain in patients undergoing laparoscopic cholecystectomy. The Cochrane Library, PubMed, EMBASE, China National Knowledge Infrastructure, and Wanfang databases were searched from the time of database creation until February 2023. We performed a randomised controlled trial on the effect of dexmedetomidine as an adjunct to local wound infiltration anaesthesia on postoperative wound pain in patients undergoing laparoscopic cholecystectomy. Two investigators independently screened the literature, extracted data, and evaluated the quality of each study. This study was performed using the Review Manager 5.4 software. Ultimately, 13 publications with 1062 patients were included. The results showed that dexmedetomidine was effective as an adjunct to local wound infiltration anaesthesia at 1\u2009h (standardised mean difference [SMD]: \u22125.31, 95% confidence intervals [CIs]: \u22127.22 to \u22123.40,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001), 4\u2009h (SMD: \u22123.40,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001), 12\u2009h (SMD: \u22122.11, 95% CIs: \u22123.10 to \u22121.13,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001) and 24\u2009h postoperatively (SMD: \u22121.98, 95% CIs: \u22122.76 to \u22121.21,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001) significantly reduced surgical site wound pain. However, there was no significant difference in the analgesic effect at 48\u2009h postoperatively (SMD: \u22121.33, 95% CIs: \u22123.25 to \u22120.58,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u2009.17). Dexmedetomidine provided good postoperative wound analgesia at the surgical site when used for laparoscopic cholecystectomy.\n                  <\/jats:p>","DOI":"10.1111\/iwj.14256","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:47:19Z","timestamp":1686617239000},"page":"3657-3664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["RETRACTED: Effects of dexmedetomidine on surgical site wound pain in patients undergoing laparoscopic cholecystectomy: A meta\u2010analysis"],"prefix":"10.1111","volume":"20","author":[{"given":"Jinhui","family":"Weng","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Shanxi Province Cancer Hospital  Taiyuan Shanxi China"},{"name":"Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences  Taiyuan Shanxi China"},{"name":"Cancer Hospital Affiliated to Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhoujun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Shanxi Province Cancer Hospital  Taiyuan Shanxi China"},{"name":"Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences  Taiyuan Shanxi China"},{"name":"Cancer Hospital Affiliated to Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shupeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Shanxi Province Cancer Hospital  Taiyuan Shanxi China"},{"name":"Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences  Taiyuan Shanxi China"},{"name":"Cancer Hospital Affiliated to Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2021.06.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10214842"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/274516"},{"key":"e_1_2_8_5_1","first-page":"77","article-title":"Effect of 1% lidocaine stellate ganglion block on circulatory function and immune function in patients undergoing elective laparoscopic cholecystectomy","volume":"14","author":"Zi CN","year":"2019","journal-title":"Chin Med"},{"key":"e_1_2_8_6_1","unstructured":"ChenFL XiangHH LinJ.Effect of Hydromorphone on Early Recovery Postoperative Analgesia and Stress Response in Patients after Radical Colorectal Cancer Surgery.202128:4."},{"key":"e_1_2_8_7_1","first-page":"2","article-title":"Effect of different anesthesia methods on stress response in patients undergoing upper abdominal surgery","volume":"38","author":"Sun M","year":"2012","journal-title":"Jiangsu Med"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000184131.06529.35"},{"key":"e_1_2_8_9_1","first-page":"40","article-title":"Comparison of bupivacaine\u2010fentanyl versus bupivacaine\u2010morphine for patient controlled epidural analgesia","volume":"17","author":"G\u00fcrkan Y","year":"2005","journal-title":"Agri"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-70942006000200002"},{"key":"e_1_2_8_11_1","first-page":"687","article-title":"Effects of dexmedetomidine on patients undergoing laparoscopic surgery for colorectal cancer","volume":"267","author":"Sun W","year":"2021","journal-title":"Research"},{"key":"e_1_2_8_12_1","unstructured":"Chinese Drugs and Clinics WJ. 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