{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T08:39:47Z","timestamp":1792485587093,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG3L1222"],"award-info":[{"award-number":["CMRPG3L1222"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aims to investigate whether the current wound classifications were valid for the treatment prognosis of subjects treated for limb\u2010threatening diabetic foot ulcers (LTDFU). A total of 1548 patients with LTDFU and infection were studied, with wounds recorded using the Wagner, Texas, PEDIS and WIfI classifications while major lower extremity amputations (LEAs) or in\u2010hospital mortality incidences were defined as poor outcomes. Among them, 153 (9.9%) patients received major LEAs and 38 (2.5%) patients died. After adjustments, the Wagner classification and Texas stage as well as clinical factors such as comorbidity with major adverse cardiac events (MACE), being under dialysis and having serum levels of C\u2010reactive protein (CRP) and albumin were independent factors for prognosis. For patients without dialysis, Wagner and Texas stage stood out independently for prognosis. For patients on dialysis, only levels of CRP (odds ratio [OR]\u2009=\u20092.2 in Wagner, OR\u2009=\u20092.0 in WIfI, OR\u2009=\u20092.2 in Texas, OR\u2009=\u20092.3 in PEDIS) and albumin (OR\u2009=\u20090.4 in four classifications) were valid predictors. The Wagner system and Texas stage were valid for predicting prognosis in treatment for LTDFUs, suggesting a role of vascular perfusion. MACE history, levels of CRP and albumin level should assist in prediction; more significantly, only levels of CRP and albumin appeared valid for those subjects undergoing dialysis.<\/jats:p>","DOI":"10.1111\/iwj.14338","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T08:22:22Z","timestamp":1691569342000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Are current wound classifications valid for predicting prognosis in people treated for limb\u2010threatening diabetic foot ulcers?"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3743-9211","authenticated-orcid":false,"given":"Ya\u2010Chu","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism Chang Gung Memorial Hospital at Linkou  Taoyuan City 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