{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:57:57Z","timestamp":1790740677017,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T00:00:00Z","timestamp":1693699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the healing effect of a new dehydrated amnion\/chorion membrane with a spongy layer over a 30\u2010month period in 32 patients with 53 chronic non\u2010healing wounds of different aetiologies. Wounds with &lt;40% surface reduction after 4\u2009weeks of best wound treatment underwent weekly allograft application by a certified wound specialist based on national guidelines and a standardised protocol until complete healing or definite treatment interruption. The main outcome measure was the percentage of wound surface reduction from baseline calculated using digital planimetry follow\u2010up photographs. Overall, 38 (71.7%) wounds presented a favourable outcome (70%\u2013100% area reduction), with 35 (66%) completely healing over a median time of 77\u2009days (range 29\u2013350\u2009days). Favourable outcomes were observed in 75% of traumatic wounds, surgical wounds, venous leg ulcers and pressure injuries, as well as in 50% of ischaemic wounds. Wounds being present &lt;12\u2009months were significantly more likely to have a favourable outcome than more long\u2010standing wounds (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u20097.799; <jats:italic>p<\/jats:italic>\u2009=\u20090.005; OR\u2009=\u20093.378; 95% CI, 1.410\u20138.092). Thus, treatment with dehydrated amnion\/chorion membrane with a spongy layer improves the outcome of non\u2010healing wounds of different aetiologies and, therefore, has to be considered early in the management of refractory wounds.<\/jats:p>","DOI":"10.1111\/iwj.14356","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T02:01:20Z","timestamp":1693792880000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dehydrated human amnion\/chorion membrane allograft with spongy layer to significantly improve the outcome of chronic non\u2010healing wounds"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0723-7014","authenticated-orcid":false,"given":"Emmanouil","family":"Psathas","sequence":"first","affiliation":[{"name":"Department of Surgery HFR\u2014Fribourg Cantonal Hospital  Fribourg Switzerland"},{"name":"Faculty of Science and Medicine University of Fribourg  Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Egger","sequence":"additional","affiliation":[{"name":"Department of Surgery HFR\u2014Fribourg Cantonal Hospital  Fribourg Switzerland"},{"name":"Faculty of Science and Medicine University of Fribourg  Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Surgery HFR\u2014Fribourg Cantonal Hospital  Fribourg 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