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The disease's mortality rate has remained high for many years, mainly because of its atypical clinical presentation, which prevents many cases from being diagnosed early and accurately, resulting in patients who may die from uncontrollable septic shock and multi\u2010organ failure. But unfortunately, no diagnostic indicator can provide a certain early diagnosis of NF, and clinical judgement of NF is still based on the results of various ancillary tests combined with the patient's medical history, clinical manifestations, and the physician's experience. This review provides a brief overview of the epidemiological features of NF and then discusses the most important laboratory indicators and scoring systems currently employed to diagnose NF. Finally, the latest progress of several imaging techniques in the early diagnosis of NF and their combined application with other diagnostic indices are highlighted. We point out promising research directions based on an objective evaluation of the advantages and shortcomings of different methods, which provide a basis for further improving the early diagnosis of NF.<\/jats:p>","DOI":"10.1111\/iwj.14379","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T21:59:43Z","timestamp":1694123983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Early diagnosis of necrotizing fasciitis: Imaging techniques and their combined application"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4173-1953","authenticated-orcid":false,"given":"Xin\u2010ke","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Burns and Plastic Surgery Second Affiliated Hospital of Air Force Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010yi","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery Second Affiliated Hospital of Air Force Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery Second Affiliated Hospital of Air Force Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery Second Affiliated Hospital of Air Force Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-018-1838-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000001187"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9371"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06103-0"},{"issue":"2","key":"e_1_2_10_6_1","first-page":"85","article-title":"Evaluation of factors affecting mortality in Fournier's gangrene: retrospective clinical study of sixteen cases","volume":"30","author":"Oymac\u0131 E","year":"2014","journal-title":"Ulus Cerrahi Derg"},{"key":"e_1_2_10_7_1","unstructured":"vonGlinskiM DadrasM WallnerC WagnerJM BehrB LehnhardtM.[Necrotizing Fasciitis]. 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