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Morphological and functional abnormalities of the venous system led to chronic venous insufficiency (CVI), and present as leg heaviness\/achiness, edema, telangiectasia, and varices. The term \u2018chronic venous insufficiency\u2019 (CVI) refers to a disease of greater severity. Venous dysfunction is associated with venous hypertension and is associated with venous reflux due to poorly functioning or incompetent venous valves, which ultimately reduces venous return, leading to a cascade of morphological, physiological, and histologic abnormalities such as blood pooling, hypoxia, inflammation, swelling, skin changes (lipodermatosclerosis), and in severe cases, venous leg ulcers (VLU). This review summarizes recent knowledge about the aetiology, risk factors, and pathophysiology of VLU and compared the possibilities of their treatment.<\/jats:p>","DOI":"10.1111\/iwj.14405","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:53:52Z","timestamp":1697763232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Chronic venous insufficiency and venous leg ulcers: Aetiology, on the pathophysiology\u2010based treatment"],"prefix":"10.1111","volume":"21","author":[{"given":"Olga","family":"Krizanova","sequence":"first","affiliation":[{"name":"Institute of Clinical and Translational Research Biomedical Research Center SAS  Bratislava Slovakia"},{"name":"Department of Chemistry, Faculty of Natural Sciences University of Ss. 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