{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:54:47Z","timestamp":1773874487321,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Toxic reactions can appear after pressurised flushing of soft tissue with octenidine (OCT) containing disinfectants. Their use for surgical disinfection could complicate the diagnosis of possible contamination. In patients with open lacerations of their hand's subcutaneous tissue samples were taken before and after surgical disinfection with Octenisept\u00ae and analysed by ultra\u2010high\u2010performance liquid chromatography coupled to tandem mass spectrometry (LC\u2013MS\/MS). In 16 out of 20 tissue samples, OCT was detected after disinfection (lower limit of quantification (LLOQ)=10\u2009pg\/mL\/mg). The concentration of OCT was below the LLOQ, estimation of mean of 0.6\u2009pg\/mL\/mg (0.22\u20130.98\u2009pg\/mL\/mg, 95%\u2010CI) before disinfection and mean of 179.4\u2009pg\/mL\/mg (13.35\u2013432.0\u2009pg\/mL\/mg, 95%\u2010CI) after disinfection. This study shows that the disinfection of open wounds with Octenisept\u00ae leads to a quantifiable concentration of OCT in open wounds. In cases of suspected OCT\u2010mediated toxic reaction, the use of antiseptics containing OCT should be avoided.<\/jats:p>","DOI":"10.1111\/iwj.14425","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T07:56:40Z","timestamp":1697529400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A prospective study to analyse the concentration of octenidine in hand wounds after disinfection by\n                    <scp>LC\u2013MS<\/scp>\n                    \/\n                    <scp>MS<\/scp>"],"prefix":"10.1111","volume":"21","author":[{"given":"Susanne","family":"Langen","sequence":"first","affiliation":[{"name":"Department of Plastic and Hand Surgery, Inselspital Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"L\u00f6tscher","sequence":"additional","affiliation":[{"name":"Department 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