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We searched databases to screen studies, ascertained the variables to be analysed, extracted the data and applied meta\u2010analysis to each qualified variable. Odds ratios and mean differences were considered to be the effect sizes for binary and continuous variables, respectively. A random\u2010effects model was used for these procedures. The source of heterogeneity was evaluated using a meta\u2010regression. Publication bias was tested by funnel plot and Egger's test, the significant results of which were then calculated using trim and fill analysis. We used a sensitivity analysis and bubble chart to describe their robustness. After screening all variables in the eligible literature, we excluded 55 because only one or no research found them significant after multivariate analysis, leaving 33 variables for synthesis. Two binary variables (age over 65\u2009years, NYHA class &gt;2) and a continuous variable (preoperative stay) were not significant after the meta\u2010analysis. The most robust independent risk factors in our study were diabetes mellitus, obesity, use of bilateral internal thoracic arteries, chronic obstructive pulmonary disease, prolonged surgery time, prolonged ventilation and critical preoperative state, followed by congestive heart failure, atrial fibrillation, renal insufficiency, stroke, peripheral vascular disease and use of an intra\u2010aortic balloon pump. Relatively low\u2010risk factors were emergent\/urgent surgery, smoking, myocardial infarction, combined surgery and coronary artery bypass grafting. Sternal wound infection after open\u2010heart surgery is a multifactorial disease. The detected risk factors significantly affected the wound healing process, but some were different in strength. Anything that affects wound healing and antibacterial ability, such as lack of oxygen, local haemodynamic disorders, malnutrition condition and compromised immune system will increase the risk, and this reminds us of comprehensive treatment during the perioperative period.<\/jats:p>","DOI":"10.1111\/iwj.14457","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T05:48:40Z","timestamp":1698817720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Risk factors for sternal wound infection after open\u2010heart operations: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2732-1328","authenticated-orcid":false,"given":"Dongsheng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery The First Medical Centre of Chinese PLA General Hospital  Beijing 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