{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:06:35Z","timestamp":1767164795770,"version":"build-2238731810"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T00:00:00Z","timestamp":1701734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In a meta\u2010study, we evaluated the effectiveness and security of the combination of topical anaesthetic and dexmedetomidine in the treatment of postoperative pain in patients with lumbar disease. Four databases were systematically searched for possible related articles. Only English\u2010language research was taken into account on the Internet. Furthermore, we only took into account the studies that were published prior to 2023. Only those that fulfilled the eligibility criteria were considered: (1) in adults who were about to undergo spine operation, (2) dexmedetomidine combined with local anaesthesia, (3) Visual Analog Scale scores at 4 and 24\u2009h after the event and (4) this was a randomized or nonrandomized, controlled study. The meta\u2010analysis was carried out with Revman 5.3 software. A ROBINS\u2010I\u2010based instrument was used to evaluate controlled studies. All trials were synthesized by computing the end results with either a fixed or a random effect model, which was dependent on statistical diversity. Five trials showed a marked reduction in wound pain at 4\u2009h after the operation in patients who were treated with dexmedetomidine for lumbar spinal surgery (MD, \u22120.81; 95% CI, \u22121.24, \u22120.35;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0005). In the case of lumbar spinal operations, the addition of dexmedetomidine to the postoperative treatment resulted in a marked reduction in the pain at 24\u2009h post\u2010operation (MD, \u22120.64; 95% CI, \u22120.79, \u22120.48;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). The quality of the data we evaluated was \u2018moderate\u2019 to \u2018good\u2019; thus, we have limited confidence in the impact estimation, and the actual impact might be significantly different from what we had expected. Additional studies should concentrate on practices that are well known to cause severe postoperative pain, especially for cases where the improvement of pain management may lead to substantial clinical benefits in terms of reduction of morbidity or cost\u2010effectiveness in terms of quicker healing and release.\n                  <\/jats:p>","DOI":"10.1111\/iwj.14523","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T03:30:00Z","timestamp":1701747000000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["RETRACTED: Effect of wound infiltration of dexmedetomidine in lumbar spine surgery on postoperative wound pain: A meta\u2010analysis"],"prefix":"10.1111","volume":"21","author":[{"given":"Xiaoping","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology People's Hospital of Chongqing Liang jiang New Area  Chongqing 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