{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:32:15Z","timestamp":1767166335047,"version":"build-2238731810"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Thrombophlebitis is the inflammatory condition characterized by obstruction of one or more vessels, commonly in the legs, due to the formation of blood clots. It has been reported that traditional Chinese medicine, including Mailuoning injection, is advantageous for treating inflammatory and blood disorders. This research assessed the therapeutic efficacy of Mailuoning injection in the treatment of thrombophlebitis in rodents, as well as investigated its impact on fibrinolysis, inflammation, and coagulation. An experimental setup for thrombophlebitis was established in rodents via modified ligation technique. Five groups comprised the animals: sham operation group, model group, and three Mailuoning treatment groups (low, medium, and high dosages). The pain response, edema, coagulation parameters (PT, APTT, TT, FIB), serum inflammatory markers (IL\u20106, TNF\u2010\u03b1, CRP), and expression levels of endothelial markers (ICAM\u20101, VCAM\u20101, NF\u2010\u03baB) were evaluated. Blood flow and vascular function were further assessed by measuring hemorheological parameters and the concentrations of TXB2, ET, and 6\u2010k\u2010PGF1\u03b1. In contrast to the sham group, model group demonstrated statistically significant increases in endothelial expression levels, coagulation latencies, and inflammatory markers (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The administration of mailing, specifically at high and medium dosages, resulted in a substantial reduction in inflammatory markers, enhancement of coagulation parameters, suppression of ICAM\u20101 and VCAM\u20101 expression, and restoration of hemorheological measurements to baseline (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Significantly higher concentrations of 6\u2010k\u2010PGF1\u03b1 and lower levels of TXB2 and ET were observed in high\u2010dose group, suggesting that pro\u2010 and anti\u2010thrombotic factors were restored to equilibrium. Utilization of Mailuoning injection in rat model of thrombophlebitis exhibited significant therapeutic impact. This effect was manifested through pain alleviation, diminished inflammation, enhanced blood viscosity and facilitation of fibrinolysis. The study indicated that Mailuoning injection may serve as a viable therapeutic option for thrombophlebitis, potentially aiding in the improvement of wound healing by virtue of its anti\u2010inflammatory and blood flow\u2010enhancing characteristics.\n                  <\/jats:p>","DOI":"10.1111\/iwj.14527","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T07:10:39Z","timestamp":1702537839000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["RETRACTED: Assessing Mailuoning injection in wound healing and thrombophlebitis management: A rat model study"],"prefix":"10.1111","volume":"21","author":[{"given":"Junqi","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery The First Affiliated Hospital of Gannan Medical University  Ganzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery the First Affiliated Hospital of Gannan Medical College  Ganzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery The First Affiliated Hospital of Gannan Medical University  Ganzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical Big Data Center The First Affiliated Hospital of Gannan Medical College  Ganzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery The First Affiliated Hospital of Gannan Medical University  Ganzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xunhong","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery The First Affiliated Hospital of Gannan Medical University  Ganzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhibiao","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery The First Affiliated Hospital of Gannan Medical University  Ganzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery The First Affiliated Hospital of Gannan Medical University  Ganzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5748-9065","authenticated-orcid":false,"given":"Qing","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery The First Affiliated Hospital of Gannan Medical University  Ganzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00552-1"},{"key":"e_1_2_9_3_1","volume-title":"Superficial Thrombophlebitis","author":"Czysz A","year":"2023"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S15562"},{"key":"e_1_2_9_5_1","volume-title":"Migratory Thrombophlebitis","author":"Jinna S","year":"2023"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000001177"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(02)00387-0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1038906"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X2050086X"},{"issue":"2","key":"e_1_2_9_10_1","first-page":"103","article-title":"Therapeutic potentials of pentoxifylline for treatment of cardiovascular diseases. Exp","volume":"9","author":"Zhang M","year":"2004","journal-title":"Clin Cardiol"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2022.2125600"},{"key":"e_1_2_9_12_1","article-title":"Mailuoning for acute ischaemic stroke","volume":"1","author":"Yang W","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025608"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/5606021"},{"issue":"3","key":"e_1_2_9_15_1","article-title":"Pharmacological treatment for Buerger's disease","volume":"3","author":"Cacione DG","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2016.03.028"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X1304150831120428"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5049.144643"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.03943.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319706297643"},{"issue":"2","key":"e_1_2_9_21_1","article-title":"Treatment for superficial thrombophlebitis of the leg","volume":"2","author":"Di Nisio M","year":"2018","journal-title":"Cochrane Database Syst Rev"}],"updated-by":[{"DOI":"10.1111\/iwj.70476","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"record-id":"65189"},{"DOI":"10.1111\/iwj.70476","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000}}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.14527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T06:29:07Z","timestamp":1754288947000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.14527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,14]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/iwj.14527"],"URL":"https:\/\/doi.org\/10.1111\/iwj.14527","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,14]]},"assertion":[{"value":"2023-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14527"}}