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A systematic review of four databases identified 16 randomized clinical trials, including 20 study groups. PRP significantly enhanced complete ulcer healing, exhibiting an odds ratio (OR) of 5.06 (95% confidence interval [CI]: 2.35\u201310.89), and increased the percentage of healed ulcer area by a mean difference of 47% (95% CI: 32%\u201362%). Additionally, PRP shortened the time required for complete healing by an average of 3.25\u2009months (95% CI: \u22124.06 to \u22122.43). Although pain reduction was similar in both groups, PRP considerably decreased ulcer recurrence rates (OR\u2009=\u20090.16, 95% CI: 0.05\u20130.50) without increasing the risks of infection or irritative dermatitis. These results suggest PRP as a viable, safe alternative for venous ulcer treatment, providing significant improvements in healing outcomes.<\/jats:p>","DOI":"10.1111\/iwj.14736","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T23:54:24Z","timestamp":1708041264000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy and safety of platelet\u2010rich plasma in the treatment of venous ulcers: A systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5414-4467","authenticated-orcid":false,"given":"Zhonglin","family":"Hu","sequence":"first","affiliation":[{"name":"Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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