{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:27:55Z","timestamp":1785875275466,"version":"3.56.0"},"reference-count":76,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This systematic review aimed to qualitatively synthesize recent randomized controlled trials (RCTs) regarding the effect of topical application and oral intake of herbal products on the healing of diabetic foot ulcer (DFU). Also, we sought to pool the obtained findings in a meta\u2010analysis using a random\u2010effects model, if RCTs were relatively comparable and homogenous. A comprehensive search was performed on five electronic data sources from their inception through 23 January 2024. The RCTs, without restriction on the country of origin, were included if they compared the effect of administering standard treatments and\/or placebo (i.e. control condition) to applying standard treatments and\/or herbal products in topical or oral routes (i.e. experimental condition). Out of 1166 retrieved records, 28 RCTs were included. Studies used different poly and single herbal formulations. Based on the meta\u2010analysis, administration of standard care plus daily dressing of the ulcer site with olive oil for 28\u2009days significantly increased the total ulcer healing score (3 RCTs; weighted mean difference [WMD]\u2009=\u200989.30;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), raised frequency of complete ulcer healing (2 RCTs; risk ratio [RR]\u2009=\u200912.44;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.039) and declined ulcer degree (3 RCTs; WMD\u2009=\u2009\u221222.28;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002). Also, daily use of the bitter melon leaf extract in oral form for 28\u2009days significantly increased the total ulcer healing score (2 RCTs; WMD\u2009=\u20090.40;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). Additionally, based on qualitative synthesis, the adjuvant use of herbal agents seems an intriguing choice to manage DFU. Nonetheless, considering the undesirable methodological quality of most studies and the high heterogeneity in administered herbal formulations, more robust trials are required to build a solid conclusion regarding the use of herbal products for healing DFU.\n                  <\/jats:p>","DOI":"10.1111\/iwj.14760","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T23:49:08Z","timestamp":1707954548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Healing of diabetic foot ulcer with topical and oral administrations of herbal products: A systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"21","author":[{"given":"Mina","family":"Zamanifard","sequence":"first","affiliation":[{"name":"Department of Nursing, School of Nursing and Midwifery Jahrom University of Medical Sciences  Jahrom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Nasiri","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, School of Allied Medical Sciences Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Yarahmadi","sequence":"additional","affiliation":[{"name":"Department of Nursing, Broujerd School of Nursing Lorestan University of Medical Sciences  Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Zonoori","sequence":"additional","affiliation":[{"name":"Department of Nursing, Broujerd School of Nursing Lorestan University of Medical Sciences  Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omolbanin","family":"Razani","sequence":"additional","affiliation":[{"name":"Department of Nursing, Doroud Branch Islamic Azad University  Doroud Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Salajegheh","sequence":"additional","affiliation":[{"name":"Department of Medical\u2010Surgical Nursing, School of Nursing and Midwifery Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Imanipour","sequence":"additional","affiliation":[{"name":"Department of Medical\u2010Surgical Nursing, Faculty of Nursing Aja University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mohammad","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, School of Medicine Abadan University of Medical Sciences  Abadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabi","family":"Jomehzadeh","sequence":"additional","affiliation":[{"name":"Department of Medical Bacteriology, School of Medicine Abadan University of Medical Sciences  Abadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3355-0821","authenticated-orcid":false,"given":"Masoomeh","family":"Asadi","sequence":"additional","affiliation":[{"name":"Department of Operating Room Nursing Abadan University of Medical Sciences  Abadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2016.03.004"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605221087815"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050312120987385"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2016.1231932"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v10.i3.200"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14179"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109155"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347346221109057"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14403"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i1.37"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347346221097283"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13318"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13377"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14320"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13858"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14427"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14135"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v13.i1.27"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.22034\/hbb.2023.01"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2019.653\u2010663"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.15253\/2175\u20106783.20232485110"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.20959\/wjpr20209\u201018360"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399818666220318095320"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2022.2034069"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557518666181025155204"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.52794\/hujpharm.1167357"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v11.i17"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaim.2023.100745"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.25270\/wnds\/2021.207218"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15010281"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2019.03.007"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2009.0470"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2022.101707"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4730896"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0254-6272(18)30036-0"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14536"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14563"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753\u20100407.12117"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/418679"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foot.2012.03.001"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.10.040"},{"issue":"7","key":"e_1_2_10_43_1","first-page":"S166","article-title":"The efficacy and side effects of oral Centella asiatica extract for wound healing promotion in diabetic wound patients","volume":"93","author":"Paocharoen V","year":"2010","journal-title":"J Med Assoc Thai"},{"issue":"2","key":"e_1_2_10_44_1","first-page":"168","article-title":"A pilot study on the effects of a polyherbal formulation cream on diabetic foot ulcers","volume":"134","author":"Viswanathan V","year":"2011","journal-title":"Indian J Med Res"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100034\u20101396315"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/1505"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2022.9503"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2022.102678"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347346221143222"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734619851700"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.12659\/msm.923424"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.2147\/ccid.s198577"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570163815666180115093007"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0080\u2010623420160000500013"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2017.06.010"},{"issue":"6","key":"e_1_2_10_56_1","first-page":"520","article-title":"Effects of topical Kiwifruit on healing of neuropathic diabetic foot ulcer","volume":"19","author":"Mohajeri G","year":"2014","journal-title":"J Res Med Sci"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40200\u2010015\u20100167\u20109"},{"issue":"1","key":"e_1_2_10_58_1","first-page":"41","article-title":"Clinical application of oral form of ANGIPARSTM and in combination with topical form as a new treatment for diabetic foot ulcers: A randomized clinical trial","volume":"16","author":"Bahrami A","year":"2008","journal-title":"DARU"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029606290133"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_10_61_1","volume-title":"GRADE Handbook: Introduction to GRADE Handbook","author":"Sch\u00fcnemann H","year":"2013"},{"key":"e_1_2_10_62_1","volume-title":"Cochrane handbook for systematic reviews of interventions version 6.3","author":"Higgins JPT","year":"2022"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/biom.12817"},{"issue":"1","key":"e_1_2_10_64_1","first-page":"29","article-title":"Limb salvage in extensive diabetic foot ulceration: An extended study using a herbal supplement","volume":"14","author":"Leung PC","year":"2008","journal-title":"Hong Kong Med J"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.5455\/njppp.2021.10.09238202008092020"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9924725"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.22607"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6957"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347346211048371"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2019.100301"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519858033"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010018\u20100684\u20102"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.4314\/ajtcam.v9i3.21"},{"key":"e_1_2_10_74_1","first-page":"8","article-title":"Medicinal herbs: Why to include in diabetic foot ulcer therapy? A review","volume":"10","author":"Ande SN","year":"2022","journal-title":"Innov Pharm Pharmacother"},{"issue":"5","key":"e_1_2_10_75_1","first-page":"12","article-title":"Examination of complementary and supportive practices and self\u2010efficacy against foot ulcers in diabetic patients","volume":"29","author":"Sahin ZA","year":"2023","journal-title":"Altern Ther Health Med"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijotn.2022.100953"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2019.05.009"}],"updated-by":[{"DOI":"10.1111\/iwj.14875","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000}}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.14760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T07:34:40Z","timestamp":1764660880000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.14760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":76,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/iwj.14760"],"URL":"https:\/\/doi.org\/10.1111\/iwj.14760","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"2024-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14760"}}