{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:26:31Z","timestamp":1767165991607,"version":"build-2238731810"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study was conducted to determine whether Naoxintong capsules may enhance wound healing and reduce postoperative complications in individuals having craniotomies. A total of 120 patients at Tongji Hospital, Shanghai, participated in this clinical perspective study conducted from April 2022 to June 2023. Participants were divided into treatment group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200960), receiving standard care plus Naoxintong capsules and control group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200960), receiving standard care only. Primary outcomes included the rate of wound healing, while secondary outcomes encompassed postoperative complications and patient\u2010reported outcomes on pain and quality of life. The treatment group exhibited significantly enhanced wound healing rate than the control at Day 7 (40.33 vs. 25.67%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), Day 14 (75.17 vs. 50.83%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and Day 28 (94.83 vs. 79.50%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Postoperative complications were markedly reduced in the treatment group, with lower rates of infection (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), wound dehiscence (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and cerebrospinal fluid leakage (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Furthermore, patient\u2010reported outcomes significantly favoured the treatment group, with reduced pain scores and improved quality of life at 4\u2009weeks post\u2010surgery(\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Naoxintong capsules thus significantly enhanced the wound healing and reduced postoperative complications, contributing to improved patient\u2010reported outcomes in post\u2010craniotomy patients. These findings advocated for the integration of Naoxintong in postoperative care, highlighting the potential of traditional Chinese medicine in modern surgical recovery protocols. Further studies with larger cohorts are recommended to validate these findings and explore the underlying mechanisms.\n                  <\/jats:p>","DOI":"10.1111\/iwj.14806","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T02:04:12Z","timestamp":1709085852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["RETRACTED: Assessing the efficacy of Naoxintong capsules on wound healing in\n                    <scp>post\u2010craniotomy<\/scp>\n                    patients: A clinical perspective"],"prefix":"10.1111","volume":"21","author":[{"given":"Guojiang","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Neurology Jiading District Central Hospital Affiliated Shaighai University of Medicine &amp; Health Sciences  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology Tongji Hospital of Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayesha","family":"Humayun","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies Pir Mehr Ali Shah Arid University  Rawalpindi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7040-159X","authenticated-orcid":false,"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Jiading District Central Hospital Affiliated Shaighai University of Medicine &amp; Health Sciences  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"StatPearls [Internet]","author":"Singh K","year":"2024"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12663\u2010016\u20100880\u2010z"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509359125"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.722975"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5892306"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2021.1877735"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12993"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.5.JNS081481"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060\u2010018\u201003058\u2010y"},{"issue":"1","key":"e_1_2_9_11_1","first-page":"445","article-title":"Wound healing activity of a traditional Chinese medicine (Longxuejie) in capsule dosage form","volume":"33","author":"Lingli G","year":"2020","journal-title":"Pak J Pharm Sci"},{"issue":"11","key":"e_1_2_9_12_1","first-page":"1530","article-title":"Clinical study on naoxintong capsule for stroke recovery of qi\u2010deficiency and blood\u2010stasis syndrome","volume":"36","author":"Su L","year":"2011","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010021\u201005264\u2010y"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5MB00460H"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00067.2017"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/UPO9781922064004.024"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15112360"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004267"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000002682"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.5812\/kowsar.22287523.1810"},{"issue":"1","key":"e_1_2_9_21_1","first-page":"11","article-title":"Recent advances in postoperative pain management","volume":"83","author":"Vadivelu N","year":"2010","journal-title":"Yale J Biol Med"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gerinurse.2017.11.003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001920.pub3"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2023.1121976"}],"updated-by":[{"DOI":"10.1111\/iwj.70538","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000}}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.14806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T15:41:30Z","timestamp":1759246890000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.14806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,27]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/iwj.14806"],"URL":"https:\/\/doi.org\/10.1111\/iwj.14806","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,27]]},"assertion":[{"value":"2024-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14806"}}