{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:49:12Z","timestamp":1792759752979,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To gain a greater understanding of how compression therapy affects quality of life, this systematic review appraised existing published studies measuring the impact of compression therapy on health quality of life (HRQoL), and pain, among people with venous leg ulcers (VLU).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Five databases were searched, and two authors extracted data and appraised the quality of selected papers using the RevMan risk of bias tool. Due to heterogeneity in the types of compression and instruments used to evaluate HRQoL, meta\u2010analysis was not appropriate; thus, a narrative synthesis of findings was undertaken.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten studies were included, 9 RCTs and one before\u2010after study. The studies employed nine different HRQoL tools to measure the impact of a variety of compression therapy systems, with or without an additional exercise programme, versus other compression systems or usual care, and the results are mixed. With the use of the Cardiff Cardiff Wound Impact Schedule, the SF\u20108 and the SF\u201012, study authors found no differences in QoL scores between the study groups. This is similar to one study using QUALYs (Iglesias et al., 2004). Conversely, for studies using EuroQol\u20105D, VEINES\u2010QOL, SF\u201036 and CIVIQ\u201020 differences in QoL scores between the study groups were noted, in favour of the study intervention groups. Two further studies using QUALYs found results that favoured a two\u2010layer cohesive compression bandage and the TLCCB group, respectively. Results for the five studies that assessed pain are also mixed, with one study finding no difference between study groups, one finding that pain increased over the study period and three studies finding that pain reduced in the intervention groups. All studies were assessed as being at risk of bias in one or more domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Results were varied, reflecting uncertainty in determining the impact of compression therapy on quality of life and pain among people with a venous leg ulcer. The heterogeneity of the compression systems and the measures used to evaluate HRQoL make it a challenge to interpret the overall evidence. Further studies should strive for homogeneity in design, interventions and comparators to enhance both internal and external validity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iwj.14816","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T06:19:38Z","timestamp":1709705978000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A systematic review of the impact of compression therapy on quality of life and pain among people with a venous leg ulcer"],"prefix":"10.1111","volume":"21","author":[{"given":"Declan","family":"Patton","sequence":"first","affiliation":[{"name":"Skin Wounds and Trauma Research Centre RCSI University of Medicine and Health Sciences  Dublin Ireland"},{"name":"School of Nursing and Midwifery RCSI University of Medicine and Health Sciences  Dublin Ireland"},{"name":"Fakeeh College of Health Sciences  Jeddah Saudi Arabia"},{"name":"School of Nursing and Midwifery 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