{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T19:19:21Z","timestamp":1780946361786,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T00:00:00Z","timestamp":1711238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetic Foot Ulcers (DFUs) are a major complication of diabetes, often leading to amputation. Understanding the relationship between haematological inflammatory markers and the incidence of amputation in DFU patients with infectious complications is crucial for improving management and outcomes. This retrospective study, conducted from May 2020 to October 2022, involved 109 patients with DFUs, categorised into amputation (AM) and non\u2010amputation (NAM) groups. Patients were evaluated for various factors, including demographic data, DFU duration, and blood parameters such as haemoglobin A1c (HbA1c), haemoglobin (Hb), albumin (ALB), white blood cell count (WBC), erythrocyte sedimentation rate (ESR), procalcitonin (PCT), C\u2010reactive protein (CRP), platelet\u2010to\u2010lymphocyte ratio (PLR), neutrophil\u2010to\u2010lymphocyte ratio (NLR), and lymphocyte\u2010to\u2010monocyte ratio (LMR). Statistical analyses were performed using independent sample t\u2010tests, Mann\u2013Whitney U test and logistic regression. The univariate analysis showed no significant difference in BMI, DM duration or DFU duration between groups. However, significant differences were noted in PCT, Hb, ESR, ALB, HbA1c and WBC levels, and in inflammatory ratios (NLR, PLR and LMR). Multivariate logistic regression identified CRP, NLR and PLR as independent risk factors for amputation. The study highlights CRP, PLR and NLR as key independent risk factors for amputation in patients with DFUs. These easily obtainable markers from routine blood tests can effectively aid in predicting the risk of osteomyelitis and amputation, enhancing clinical decision making and patient care strategies.<\/jats:p>","DOI":"10.1111\/iwj.14827","type":"journal-article","created":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T19:48:40Z","timestamp":1711309720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["RETRACTED: The impact of inflammatory biomarkers on amputation rates in patients with diabetic foot ulcers"],"prefix":"10.1111","volume":"21","author":[{"given":"Yun","family":"Xu","sequence":"first","affiliation":[{"name":"Ward 1, The Department of Endocrinology The First Affiliated Hospital of Xinxiang Medical University  Weihui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruina","family":"Geng","sequence":"additional","affiliation":[{"name":"Ward 1, The Department of Endocrinology The First Affiliated Hospital of Xinxiang Medical University  Weihui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Meng","sequence":"additional","affiliation":[{"name":"Ward 1, The Department of Endocrinology The First Affiliated Hospital of Xinxiang Medical University  Weihui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Feng","sequence":"additional","affiliation":[{"name":"The Department of General Medicine The First Affiliated Hospital of Xinxiang Medical University  Weihui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"Ward 1, The Department of Endocrinology The First Affiliated Hospital of Xinxiang Medical University  Weihui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ward 2, The Department of Urology The First Affiliated Hospital of Xinxiang Medical University  Weihui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Bai","sequence":"additional","affiliation":[{"name":"Ward 1, The Department of Endocrinology The First Affiliated Hospital of Xinxiang Medical University  Weihui China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.10578"},{"issue":"2","key":"e_1_2_10_3_1","first-page":"26","article-title":"Diabetic foot infections: a comprehensive overview","volume":"23","author":"Pitocco D","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v13.i12.1106"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158278"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v13.i12.1049"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13569"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2701"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23719"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347346211057742"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007051"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S284583"},{"key":"e_1_2_10_13_1","first-page":"10","article-title":"Diabetic wound\u2010healing science","volume":"57","author":"Burgess JL","year":"2021","journal-title":"Medicina (Kaunas)"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.5152\/j.aott.2020.02.518"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14019"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14296"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.08.009"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.18323"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0043"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2018.180804"},{"issue":"1","key":"e_1_2_10_22_1","first-page":"37","article-title":"Pro\u2010calcitonin, erythrocyte sedimentation rate and C \u2010 reactive protein in predicting diabetic foot ulcer characteristics; 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