{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:00:17Z","timestamp":1759334417460,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neoadjuvant chemoimmunotherapy is becoming an increasingly important part of the management of lung cancer to facilitate surgical resection. This study aimed to summarize the treatment\u2010related adverse events (TRAEs) and wound complications of neoadjuvant chemoimmunotherapy in non\u2010small cell lung cancer (NSCLC). Eligible studies of neoadjuvant chemoimmunotherapy for NSCLC were identified from PubMed, Embase and Web of Science. The endpoints mainly included TRAEs and wound complications. Stata18 software was used for statistical analysis with <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 considered statistically significant. Twenty studies including a total of 1072 patients were eligible for this study. Among the patients who received neoadjuvant chemoimmunotherapy, the pooled prevalence of any grade TRAEs was 77% (95% confidence interval [CI] [0.64\u20130.86]), grade 1\u20132 TRAEs was 77% (95% CI [0.58\u20130.89]) and grade\u2009\u22653 TRAEs was 26% (95% CI [0.16\u20130.38]). Surgery\u2010related complications rate was 22% (95% CI [0.14\u20130.33]). Among the wound complications, the pooled rate of air leakage was 10% (95% CI [0.04\u20130.23]), pulmonary\/wound infection was 8% (95% CI [0.05\u20130.13]), bronchopleural fistula was 8% (95% CI [0.02\u20130.27]), bronchopulmonary haemorrhage was 3% (95% CI [0.01\u20130.05]), pneumonia was 5% (95% CI [0.02\u20130.10]), pulmonary embolism was 1% (95% CI [0.01\u20130.03]), pleural effusion was 7% (95% CI [0.03\u20130.14]) and chylothorax was 4% (95% CI [0.02\u20130.09]). Overall, neoadjuvant chemoimmunotherapy in NSCLC results a high incidence of grade 1\u20132 TRAEs but a low risk of increasing the incidence of \u22653 grade TRAEs and wound complications. These results need to be confirmed by more large\u2010scale prospective randomized controlled trials and studies.<\/jats:p>","DOI":"10.1111\/iwj.14831","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T19:30:25Z","timestamp":1710444625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of treatment\u2010related adverse events and wound complications of surgical resection after neoadjuvant chemoimmunotherapy for non\u2010small cell lung cancer"],"prefix":"10.1111","volume":"21","author":[{"given":"Yihang","family":"Li","sequence":"first","affiliation":[{"name":"Jiangyin Hospital of Traditional Chinese Medicine  Jiangyin Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Hu","sequence":"additional","affiliation":[{"name":"Jiangyin Hospital of Traditional Chinese Medicine  Jiangyin Jiangsu Province 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