{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:28:51Z","timestamp":1788272931628,"version":"build-2803163510"},"reference-count":63,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T00:00:00Z","timestamp":1711238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000837","name":"University of Nottingham","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this scoping review was to provide an overview of current research into topical oxygen therapies including the under\u2010researched singlet oxygen for wound healing. A scoping review was undertaken using five databases. After duplicates and ineligible studies were excluded, 49 studies were included for a narrative review. Out of the included 49 studies, 45 (91.8%) were published in the past 10\u2009years (2013\u20132023) with 32 (65.3%) published in the past 5\u2009years (2018\u20132023). Eight of the studies were systematic reviews and\/or meta\u2010analysis and 18 were RCTs. The search identified zero human RCTs on singlet oxygen, but one human cohort study and five studies in animals. There is evidence that topical oxygen therapy may be useful for the treatment of chronic wounds, mainly diabetic foot ulcers. Singlet oxygen has shown potential, but would need further confirmation in controlled human trials, including more research to understand the bio\u2010properties.<\/jats:p>","DOI":"10.1111\/iwj.14846","type":"journal-article","created":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T20:04:40Z","timestamp":1711310680000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Topical oxygen therapy and singlet oxygen in wound healing: A scoping review"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2579-5888","authenticated-orcid":false,"given":"Martina","family":"S\u00fdkorov\u00e1","sequence":"first","affiliation":[{"name":"Skin Integrity Research Group School of Health Sciences, University of Nottingham, Queen's Medical Centre  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine Joy","family":"Moffatt","sequence":"additional","affiliation":[{"name":"The Institute of Care Excellence, Nottingham University Hospitals NHS Trust, City Hospital  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Stentiford","sequence":"additional","affiliation":[{"name":"SOE Health Ltd  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0630-2694","authenticated-orcid":false,"given":"Ewa Anna","family":"Burian","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology and Wound Healing Center Bispebjerg Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasagaki","family":"Katsuhiro","sequence":"additional","affiliation":[{"name":"Medical Technologies Innovation Facility Engineering Department, School of Science and Technology, Nottingham Trent University  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wei","sequence":"additional","affiliation":[{"name":"Medical Technologies Innovation Facility Engineering Department, School of Science and Technology, Nottingham Trent University  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-045253"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09804.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2015.24.2.53"},{"issue":"4","key":"e_1_2_9_5_1","first-page":"26","article-title":"Hyperbaric oxygen therapy for problem wounds: an update","volume":"15","author":"Bishop A","year":"2019","journal-title":"Wounds UK"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2017.26.Sup5.S1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2011.20.4.149"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14585"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2021.30.10.823"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1900\/RDS.2019.15.74"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12561"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2022.0041"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12972"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13830"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3284"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.11.2.111"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296817695574"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wndm.2015.03.005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2018.27.Sup9.S30"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12490"},{"issue":"11","key":"e_1_2_9_21_1","first-page":"19","article-title":"A prospective, randomized clinical study evaluating the effect of transdermal continuous oxygen therapy on biological processes and foot ulcer healing in persons with diabetes mellitus","volume":"59","author":"Driver VR","year":"2013","journal-title":"Ostomy Wound Manage"},{"issue":"4","key":"e_1_2_9_22_1","first-page":"12","article-title":"A prospective, randomized, blinded, controlled trial comparing transdermal continuous oxygen delivery to moist wound therapy for the treatment of diabetic foot ulcers","volume":"63","author":"Driver VR","year":"2017","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2021.30.Sup5.S7"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13789"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.108743"},{"issue":"0","key":"e_1_2_9_26_1","first-page":"1","article-title":"An observational clinical trial examining the effect of topical oxygen therapy (Natrox\u2122) on the rates of healing of chronic diabetic foot ulcers (OTONAL trial)","volume":"0","author":"Tang TY","year":"2021","journal-title":"Int J Low Extrem Wounds"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2021.07.028"},{"issue":"1","key":"e_1_2_9_28_1","first-page":"50","article-title":"The efficiency of transdermal oxygen wound therapy in lower extremity venous ulcers","volume":"13","author":"Altinbas O","year":"2022","journal-title":"Ann Clin Anal Med"},{"issue":"3","key":"e_1_2_9_29_1","first-page":"1414","article-title":"Wet dressings with oxygen\u2010irrigation improves chronic wound healing","volume":"13","author":"Wang Z","year":"2020","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0476"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.20211"},{"issue":"6","key":"e_1_2_9_32_1","first-page":"24","article-title":"Topical wound oxygen therapy in the treatment of severe diabetic foot ulcers: a prospective controlled study","volume":"56","author":"Blackman E","year":"2010","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1538574412467684"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2009.03.027"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.5704\/MOJ.2011.020"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2021.0118"},{"issue":"1","key":"e_1_2_9_37_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.51847\/AOG7bQc","article-title":"Evaluation the effect of new transdermal oxygen therapy method on healing of pressure ulcer in children","volume":"10","author":"Ahmadinejad M","year":"2020","journal-title":"Int J Pharm Phytopharm Res"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.4314\/ejhs.v32i5.11"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S341448"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12262-021-03057-w"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wndm.2014.08.002"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e31829b3338"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.7547\/19-189"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2018.27.4.210"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3402\/dfa.v7.33101"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2017.26.9.558"},{"issue":"2","key":"e_1_2_9_47_1","first-page":"25","article-title":"Effect of topical haemoglobin on venous leg ulcer healing","volume":"13","author":"Arenbergerova M","year":"2013","journal-title":"EWMA J"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2021.101547"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.99060.x"},{"issue":"6","key":"e_1_2_9_50_1","first-page":"7294","article-title":"Effects of topical oxygen therapy on chronic traumatic wounds and its impact on granulation tissue","volume":"13","author":"Song Z","year":"2021","journal-title":"Am J Transl Res"},{"issue":"11","key":"e_1_2_9_51_1","first-page":"8526","article-title":"Topical oxygen therapy can reduce related symptoms of malignant fungating wounds in breast cancer: a retrospective observational case series study","volume":"13","author":"Tang J","year":"2020","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_9_52_1","first-page":"8","article-title":"Synergistic antibacterial and anti\u2010inflammatory effects of a drug\u2010loaded self\u2010standing porphyrin\u2010COF membrane for efficient skin wound healing","volume":"10","author":"Ding L","year":"2021","journal-title":"Adv Healthc Mater"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c03952"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c02503"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202101495"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202000107"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2011.0319"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010030\u201028872\u20103_12"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34254.x"},{"key":"e_1_2_9_60_1","first-page":"299","article-title":"Treatment of anaerobic infections (clostridial myositis) by drenching the tissues with oxygen under high atmospheric pressure","volume":"49","author":"Brummelkamp WH","year":"1961","journal-title":"Surgery"},{"key":"e_1_2_9_61_1","first-page":"53","article-title":"Oxygen hyperbaric treatment for carbon monoxide poisoning and severe burn in coal mine (Hokutanyubari) gas explosion","volume":"5","author":"Wada J","year":"1965","journal-title":"Igaku No Aymi"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2017.26.6.292"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-019-0782-0"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.14846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T06:30:21Z","timestamp":1754289021000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.14846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,24]]},"references-count":63,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/iwj.14846"],"URL":"https:\/\/doi.org\/10.1111\/iwj.14846","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,24]]},"assertion":[{"value":"2023-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14846"}}