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The research then examined the therapeutic efficacy of locally administered, tissue\u2010permeable HA35 in alleviating chronic wounds and their associated neuropathic pain. For 20 patients with nonhealing wounds and associated pain lasting over three\u2009months, 100\u2009mg of HA35 was injected daily into the healthy skin surrounding the chronic wound for 10\u2009days. Self\u2010assessments\u00a0before and after treatment indicated that HA35 significantly enhanced wound healing. This was evidenced by the formation of fresh granulation tissue on the wounds (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001); reduced\u00a0darkness, redness, dryness, and damage in the skin surrounding the wounds (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and a decrease in wound size (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Remarkably, HA35 injections alleviated pain associated with chronic wounds within 24\u2009hours (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). It can be concluded that the low\u2010molecular\u2010weight hyaluronan fragment HA35 potentially enhances\u00a0the immune response and angiogenesis during wound healing.<\/jats:p>","DOI":"10.1111\/iwj.14906","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T03:53:05Z","timestamp":1715745185000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A clinical study of the local injection of a freshly manufactured 35\u2009<scp>kDa<\/scp> hyaluronan fragment for treating chronic wounds"],"prefix":"10.1111","volume":"21","author":[{"given":"Dylan","family":"Treger","sequence":"first","affiliation":[{"name":"Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peripheral Vascular Department Far East Hospital  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Jia","sequence":"additional","affiliation":[{"name":"Qingdao Hui Nuo De Biotechnology Co. 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