{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:38:25Z","timestamp":1792190305718,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Surgical site infections (SSIs) following major lower limb amputation (MLLA) in vascular patients are a major source of morbidity. The objective of this systematic review was to determine the incidence of SSI following MLLA in vascular patients. This review was prospectively registered with the International Prospective Register of Systematic Reviews (CRD42023460645). Databases were searched without date restriction using a pre\u2010defined search strategy. The search identified 1427 articles. Four RCTs and 21 observational studies, reporting on 50\u2009370 MLLAs, were included. Overall SSI incidence per MLLA incision was 7.2% (3628\/50370). The incidence of SSI in patients undergoing through\u2010knee amputation (12.9%) and below\u2010knee amputation (7.5%) was higher than the incidence of SSI in patients undergoing above\u2010knee amputation, (3.9%),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001. The incidence of SSI in studies focusing on patients with peripheral arterial disease (PAD), diabetes or including patients with both was 8.9%, 6.8% and 7.2%, respectively. SSI is a common complication following MLLA in vascular patients. There is a higher incidence of SSI associated with more distal amputation levels. The reported SSI incidence is similar between patients with underlying PAD and diabetes. Further studies are needed to understand the exact incidence of SSI in vascular patients and the factors which influence this.\n                  <\/jats:p>","DOI":"10.1111\/iwj.14946","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:33:45Z","timestamp":1720053225000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The incidence of surgical site infection following major lower limb amputation: A systematic review"],"prefix":"10.1111","volume":"21","author":[{"given":"Nina","family":"Al\u2010Saadi","sequence":"first","affiliation":[{"name":"Black Country Vascular Network  Dudley UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Al\u2010Hashimi","sequence":"additional","affiliation":[{"name":"Colchester Hospital, North Essex NHS Foundation Trust  Colchester 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