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From 22 patients with 23 split skin graft donor sites, vessels at four wound edges, the wound bed, and adjacent and unaffected skin of the contralateral leg were measured by D\u2010OCT at six time points from surgery to 4\u2009weeks of healing. Changes in vessel orientation, density, diameter, morphology and pattern in horizontal, vertical and 3D images were analysed for wound healing and re\u2010epithelialization. At 300\u2009\u03bcm depth, there were significant differences of blobs and serpiginous vessels between normal and wounded skin. The wound had significantly more vertically oriented vessels, a higher degree of branching, vessel density and diameter compared with healthy skin. 3D images showed increased angiogenesis from healthy skin towards the wound centre, significantly higher vessel density at the wound than at normal skin and the highest at the interface. During wound healing blobs, coils and serpiginous vessels occurred significantly more frequently in lesional than healthy skin. Vessel density was greatest at the beginning, decreased and then increased by 4\u2009weeks post\u2010surgery. D\u2010OCT helps to evaluate acute wound healing by visualizing and quantifying blood vessel growth in addition to re\u2010epithelialization.<\/jats:p>","DOI":"10.1111\/iwj.70015","type":"journal-article","created":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T23:28:19Z","timestamp":1724282899000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Dynamic optical coherence tomography for imaging acute wound healing"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-7619","authenticated-orcid":false,"given":"Sandra","family":"Schuh","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4649-3405","authenticated-orcid":false,"given":"Maximilian","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2054-9052","authenticated-orcid":false,"given":"Stefan","family":"Schiele","sequence":"additional","affiliation":[{"name":"Institute of Mathematics University of Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8730-7596","authenticated-orcid":false,"given":"Anna","family":"Rubeck","sequence":"additional","affiliation":[{"name":"Institute of Mathematics University of Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernot","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Mathematics University of Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2893-6188","authenticated-orcid":false,"given":"Jennifer Jahel V\u00e9lez","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9477-117X","authenticated-orcid":false,"given":"Jon","family":"Holmes","sequence":"additional","affiliation":[{"name":"Michelson Diagnostics Ltd  Maidstone UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6099-7418","authenticated-orcid":false,"given":"Julia","family":"Welzel","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"749","volume-title":"Biochemie und Molekularbiologie des Menschen","author":"Neumaier M","year":"2013"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1087-0024.2000.00014.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-017-0175-4"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2016.05.004"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13680"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.33.001530"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201000103"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.18.008220"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.25.001358"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.27.001702"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3285504"},{"key":"e_1_2_11_13_1","first-page":"234","article-title":"Skin surface reconstruction and 3D vessels segmentation in speckle variance optical coherence tomography. 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