{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:43:45Z","timestamp":1790545425292,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019305","name":"Manipal Academy of Higher Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019305","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Wound Journal"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Objective of the study was to find the association of vitamin D receptor (VDR) polymorphisms (Fokl, Taql and Apal) with vitamin D levels in diabetic foot ulcer (DFU) patients in South India. In this case\u2013control study, plasma vitamin D levels and VDR genotype frequencies of 70 cases (DFU patients) were compared with 70 diabetic (diabetes mellitus [DM] [non\u2010DFU]) patients and 70 apparently healthy controls (HC) from South India. Plasma vitamin D levels were measured using the ELISA technique, and genotyping of VDR polymorphisms was carried out using real\u2010time polymerase chain reaction. Logistic regression was used to find the association between DFU versus HC and DFU versus DM traits. Association analysis was performed based on additive, dominant and recessive models with age and gender as covariates. A 45.7% of DFU patients have sufficient vitamin D levels than 48.6% and 40% of DM patients and HC, respectively. Linkage disequilibrium analysis for DFU versus HC and DFU versus DM traits shows that single nucleotide polymorphisms (SNPs) Taq1 (rs731236) and Apal (rs7975232) are in strong linkage disequilibrium in DFU patients. The alleles and genotype frequencies were similar in all three groups. Although the additive model does not show statistical significance, age and sex correlate with the three SNPs (Fokl, Taql and Apal). No association was found between VDR gene polymorphisms and vitamin D levels in DFU patients in Southern India. On the other hand, age and sex correlate with the three SNPs.<\/jats:p>","DOI":"10.1111\/iwj.70027","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T11:49:01Z","timestamp":1723636141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association of vitamin D status and vitamin D receptor polymorphism in diabetic foot ulcer patients: A prospective observational study in a South\u2010Indian tertiary healthcare facility"],"prefix":"10.1111","volume":"21","author":[{"given":"Shilia Jacob","family":"Kurian","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice Manipal College of Pharmaceutical Sciences, Manipal Academy of High Education  Manipal India"},{"name":"Manipal Centre for Infectious Diseases, Prasanna School of Public Health Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejaswini","family":"Baral","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Manipal College of Pharmaceutical Sciences, Manipal Academy of High Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruby","family":"Benson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Manipal College of Pharmaceutical Sciences, Manipal Academy of High Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murali","family":"Munisamy","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine All India Institute of Medical Sciences  Bhopal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavitha","family":"Saravu","sequence":"additional","affiliation":[{"name":"Manipal Centre for Infectious Diseases, Prasanna School of Public Health Manipal Academy of Higher Education  Manipal India"},{"name":"Department of Infectious Diseases Kasturba Medical College, Manipal, Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Sunil","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of General &amp; Laparoscopic Surgery Aster Al Raffah Hospital  Sohar Sultanate of Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sunil Krishna","sequence":"additional","affiliation":[{"name":"Department of General Surgery Kasturba Medical College, Manipal, Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahana","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Kasturba Medical College, Manipal, Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Rajendra Institute of Medical Sciences  Ranchi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonal Sekhar","family":"Miraj","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Manipal College of Pharmaceutical Sciences, Manipal Academy of High Education  Manipal India"},{"name":"Manipal Centre for Infectious Diseases, Prasanna School of Public Health Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13569"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399816999201012195735"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300\u2010012\u20100004\u20109"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117305"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12\u20100919"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2014.240"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2007.00710.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.11.012"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2020.4009"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010022\u201007698\u20102"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114514003018"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.deman.2023.100175"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1515\/dmpt-2020-0178"}],"container-title":["International Wound Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iwj.70027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T02:48:09Z","timestamp":1730688489000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iwj.70027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/iwj.70027"],"URL":"https:\/\/doi.org\/10.1111\/iwj.70027","archive":["Portico"],"relation":{},"ISSN":["1742-4801","1742-481X"],"issn-type":[{"value":"1742-4801","type":"print"},{"value":"1742-481X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70027"}}